TLR1
Based on 3 publication(s) in Google Scholar
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.
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- Pureza: 99.43%
- No. CAS: 566914-00-9
- Fòrmula: C18H26N2O2
- Peso molecular:302.41
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TLR1
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Actividad biológica
TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 566914-00-9
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Appearance Liquid
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Peso molecular 302.41
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Fòrmula C18H26N2O2
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Color Colorless to light yellow
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SMILES
O=C(N[C@H](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Publications (3)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell-cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway. [Abstract]2022 Sep;43(9):2289-2301. PMID: 35132192 -
Eur J Pharmacol
GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts. [Abstract]2022 Apr 5;920:174830. PMID: 35182545 -
Microbiol Spectr
Pseudomonas aeruginosa Induces Interferon-β Production to Promote Intracellular Survival. [Abstract]2022 Oct 26;10(5):e0155022. PMID: 36190409
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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