TP-020
Based on 1 Customer Validation
TP-020 (MGAT2-IN-1), a chemical probe, is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.94%
- No. CAS: 1800025-30-2
- Fòrmula: C27H21ClF5N7O3S
- Peso molecular:654.01
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1800025-30-2
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Appearance Solid
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Peso molecular 654.01
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Fòrmula C27H21ClF5N7O3S
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Color White to gray
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SMILES
O=S(C1=CC2=C(N(C3=NC=C(C4=CC(C(F)(F)F)=NN4C)C=N3)CC2)C(N5C(CCC5)=O)=C1)(NC6=C(F)C=C(Cl)C=C6F)=O
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Synonyms
MGAT2-IN-1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : ≥ 125 mg/mL (191.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
Mice: Overnight-fasted mice undergo MTT in the morning. First, they are orally administered vehicle (0.5% methylcellulose solution) or MGAT2-IN-1 suspended in 0.5% methylcellulose. Six or 16 h after dosing, they are intraperitoneally injected 500 mg/kg Pluronic F-127 to inhibit plasma TG hydrolysis by lipoprotein lipase (LPL). Thirty minutes after injection, the mice are given an oral liquid meal (10 mL/kg) comprising an admixture of corn oil and Ensure-H (3:17 v/v). Blood samples are collected at 0, 2 and 4 h after oral gavage of the liquid meal. Area under the curve (AUC) of chylomicron TG (CM/TG), which is synthesised from dietary fat in the small intestine, is calculated by subtracting plasma TG levels of a liquid meal-untreated group from plasma TG levels of each treated group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5290 mL | 7.6451 mL | 15.2903 mL | 38.2257 mL |
| 5 mM | 0.3058 mL | 1.5290 mL | 3.0581 mL | 7.6451 mL | |
| 10 mM | 0.1529 mL | 0.7645 mL | 1.5290 mL | 3.8226 mL | |
| 15 mM | 0.1019 mL | 0.5097 mL | 1.0194 mL | 2.5484 mL | |
| 20 mM | 0.0765 mL | 0.3823 mL | 0.7645 mL | 1.9113 mL | |
| 25 mM | 0.0612 mL | 0.3058 mL | 0.6116 mL | 1.5290 mL | |
| 30 mM | 0.0510 mL | 0.2548 mL | 0.5097 mL | 1.2742 mL | |
| 40 mM | 0.0382 mL | 0.1911 mL | 0.3823 mL | 0.9556 mL | |
| 50 mM | 0.0306 mL | 0.1529 mL | 0.3058 mL | 0.7645 mL | |
| 60 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6371 mL | |
| 80 mM | 0.0191 mL | 0.0956 mL | 0.1911 mL | 0.4778 mL | |
| 100 mM | 0.0153 mL | 0.0765 mL | 0.1529 mL | 0.3823 mL |
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