UDA-6
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.
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- Fòrmula: C193H315N51O62
- Peso molecular:4341.87
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
UDA-6 (30 min) potently and equally activates human AMY3R and human CTR in HEK-293 cells, with EC50 values of 0.8 pM and 0.6 pM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UDA-6 (10-20 nmol/kg; s.c.; daily; 24 days) induces body weight decrease and improves metabolic and hepatic parameters in male DIO SD rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lean SD Rats (male, 8-10 weeks old)[1]
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Dosage:1; 3; 10; 30 nmol/kg
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Administration:s.c.; single dose
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Result:Produced a dose-dependent reduction in body weight and cumulative food intake over 96 hours.
Caused transient food intake inhibition over 24 hours followed by rebound at 1 nmol/kg.
Induced a >10% decrease in body weight relative to vehicle controls and sustained food intake suppression over 48 hours at 30 nmol/kg.
Showed no signs of discomfort, emesis, or behavioral abnormalities at any dose.
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Animal Model:DIO SD Rats (male, 600-700 g) maintained on a high fat diet (HFD).[1]
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Dosage:10 ; 20 nmol/kg
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Administration:s.c.; daily; 24 days
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Result:Resulted in a maximum mean body weight decrease of 13.1% from baseline at 20 nmol/kg.
Reduced ad libitum fed blood glucose levels, serum AST, ALT, TG, TC, and fasting blood glucose levels relative to vehicle controls.
Reduced liver weight, hepatic TG, and hepatic TC.
Partially alleviated liver inflammation and lipid deposition via oil red O and H&E staining.
Chemical Information
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Peso molecular 4341.87
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Fòrmula C193H315N51O62
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Sequence
{Pyr}-Ser-His-Leu-Ser-Thr-Ala-Val-Leu-Gly-Arg-cyclo{Lys-(PEG2-Gly-Gly-Ser-Gly-Ser-Gly-γGlu-C20 diacid)-Ser-Ala-Glu-Glu}-His-Lys-Leu-{Aib}-Asp-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ser-Gly-Ala-Pro-NH2
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Sequence Shortening
{Pyr}-SHLSTAVLGR-cyclo{K-(PEG2-GGSGSG-γGlu-C20 diacid)-SAEE}-HKL-{Aib}-DYPRTDVGSGAP-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UDA-6 Related Classifications
HY-P11830 Related Classifications
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