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Referencia número: HY-P10878

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UK140

UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with K_i of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research.

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Fòrmula: C₇₂H₁₀₅N₁₉O₂₅S₃
Peso molecular:1732.91

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

UK140 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
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Actividad biológica

Descripciòn

UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with K_i of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research^[1].

IC₅₀ & Target

K_i: 0.20 µM (huPA); 2.79 µM (muPA)

Chemical Information

Peso molecular 1732.91

Fòrmula C₇₂H₁₀₅N₁₉O₂₅S₃

Sequence

Ala-Cys-Asn-Ser-Lys-Phe-Ser-Gly-Cys-Gly-Val-Asp-Pro-Ser-Ser-Cys-Gly (cyclized via TBMB and Cys2,9,16)

Sequence Shortening

ACNSKFSGCGVDPSSCG (cyclized via TBMB and Cys2,9,16)

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Mazzocato Y, et al., A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue. Bioorg Med Chem. 2023 Nov 15;95:117499. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Concentration Concentration

×
Volume Volume

×
Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

UK140 Related Classifications

HY-P10878 Related Classifications

Metabolic Enzyme/Protease

PAI-1

Disease Areas

Cancer

Peptides

Peptide and Derivatives

Inhibitors and Substrates

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

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Keywords

UK140
UK 140
UK-140
PAI-1
Inhibitor
inhibitor
inhibit

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UK140

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UK140 Related Classifications

HY-P10878 Related Classifications

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