UNC7467
Based on 1 Customer Validation
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.87%
- No. CAS: 2922283-43-8
- Fòrmula: C20H13NO3
- Peso molecular:315.32
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
IC50: 4.9 nM (IP6K2), 8.9 nM (IP6K1), 1320 nM (IP6K3)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
0.24 μM
Compound: 20; UNC7467
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Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 18 hrs by HPLC analysis
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[PMID: 35467861] |
| HCT-116 | EC50 |
1 μM
Compound: 20; UNC7467
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Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
Reduction in InsP8-dependent [33P]-inorganic phosphate efflux in human HCT-116 cells measured after 3 hrs by HPLC analysis
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[PMID: 35467861] |
UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily, for 4 weeks
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Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:5 mg/kg (Pharmacokinetic Analysis)
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Administration:Intravenous injection and intraperitoneal injection
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Result:
1.19 route iv ip Dose (mg/kg) 5 5 AUClast (h*ng/mL) 6054 2527 CL (mL/min/kg) 13.7
Chemical Information
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No. CAS 2922283-43-8
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Appearance Solid
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Peso molecular 315.32
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Fòrmula C20H13NO3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(ON=C2C=C1)C3=CC=C(C=C3)C4=CC=CC=C4)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 14 mg/mL (44.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1714 mL | 15.8569 mL | 31.7138 mL | 79.2845 mL |
| 5 mM | 0.6343 mL | 3.1714 mL | 6.3428 mL | 15.8569 mL | |
| 10 mM | 0.3171 mL | 1.5857 mL | 3.1714 mL | 7.9285 mL | |
| 15 mM | 0.2114 mL | 1.0571 mL | 2.1143 mL | 5.2856 mL | |
| 20 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2686 mL | 3.1714 mL | |
| 30 mM | 0.1057 mL | 0.5286 mL | 1.0571 mL | 2.6428 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL |
UNC7467 Related Classifications
HY-150607 Related Classifications
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