VT3989 (Standard)
VT3989 (Standard) is the analytical standard of VT3989 (HY-400902). This product is intended for research and analytical applications. VT3989 is an orally active pan-TEAD autopalmitoylation inhibitor that modulates the Hippo signaling pathway. VT3989 directly binds to TEAD transcription factors to block their palmitoylation modification, thereby disrupting the formation of YAP/TAZ-TEAD complexes and inhibiting downstream oncogenic transcriptional activity. VT3989 effectively inhibits the growth of NF2-deficient schwannoma and meningioma cells and reverses the Schwann cell phenotype. In addition, VT3989 exerts a synergistic effect when combined with Osimtinib (HY-15772) in EGFR-mutant non-small cell lung cancer models, significantly delaying tumor recurrence and prolonging survival. VT3989 can be used for the research of epithelioid hemangioendothelioma, malignant pleural mesothelioma, type 2 neurofibromatosis and related advanced solid tumors.
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- No. CAS: 2506273-81-8
- Fòrmula: C21H18F3NO3
- Peso molecular:389.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 2506273-81-8
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Peso molecular 389.37
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Fòrmula C21H18F3NO3
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SMILES
OC[C@@H](C)NC(C(C=C1)=CC2=C1C(OC3=CC=C(C=C3)C(F)(F)F)=CC=C2)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VT3989 (Standard) Related Classifications
HY-400902R Related Classifications
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Keywords
- VT3989 (Standard)
- 2506273-81-8
- Reference Standards
- YAP
- VEGFR
- Hippo (MST)
- merlin-depleted Schwann cells
- human-derived schwannoma cells
- YAP/TAZ-TEAD complex
- epithelioid hemangioendothelioma
- malignant pleural mesothelioma
- neurofibromatosis type 2
- vestibular schwannoma
- NF2-loss meningioma cells
- TEAD transcription factors
- EGFR mutant non-small cell lung cancer
- Inhibitor
- inhibitor
- inhibit