YD-3
YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin.
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- No. CAS: 170632-41-4
- Fòrmula: C23H20N2O2
- Peso molecular:356.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
>10 μM
Compound: YD-3
|
Inhibition of collagen-induced human platelet aggregation
Inhibition of collagen-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
|
Inhibition of SFLLRN-induced human platelet aggregation
Inhibition of SFLLRN-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
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Inhibition of thrombin-induced human platelet aggregation
Inhibition of thrombin-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
>10 μM
Compound: YD-3
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Inhibition of U46619-induced human platelet aggregation
Inhibition of U46619-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
0.13 μM
Compound: YD-3
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Inhibition of GYPGKF-induced human platelet aggregation
Inhibition of GYPGKF-induced human platelet aggregation
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[PMID: 17988878] |
| Platelet | IC50 |
164 μM
Compound: 11
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Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
Inhibition of PAF-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by PAF addition
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[PMID: 33049608] |
| Platelet | IC50 |
184.8 μM
Compound: 11
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Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
Inhibition of arachidonic acid-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by arachidonic acid addition
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[PMID: 33049608] |
| Platelet | IC50 |
212.4 μM
Compound: 11
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Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by collagen addition
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[PMID: 33049608] |
| Platelet | IC50 |
29.3 μM
Compound: 11
|
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
Inhibition of thrombin-induced platelet aggregation in human platelet-rich plasma incubated for 1 min followed by thrombin addition
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[PMID: 33049608] |
Chemical Information
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No. CAS 170632-41-4
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Peso molecular 356.42
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Fòrmula C23H20N2O2
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SMILES
O=C(OCC)C1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YD-3 Related Classifications
HY-111766 Related Classifications
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