YM511
Based on 1 Customer Validation
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.73%
- No. CAS: 148869-05-0
- Fòrmula: C16H12BrN5
- Peso molecular:354.20
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Antioxidant Compound Library
HY-L037
-
Oxygen Sensing Compound Library
HY-L045
-
Endocrinology Compound Library
HY-L047
-
Mitochondria-Targeted Compound Library
HY-L089
-
Metabolic Enzyme Compound Library
HY-L146
-
Highly Selective Inhibitors Library
HY-L158
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Metabolism/Protease Compound Library
HY-L012
-
Clinical Compound Library
HY-L026
-
Anti-Aging Compound Library
HY-L034
-
Drug Repurposing Compound Library
HY-L035
Actividad biológica
|
Aromatase |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JEG-3 | IC50 |
0.5 nM
Compound: 1
|
Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione after 1 hr by scintillation spectrometry
Inhibition of aromatase in human JEG-3 cells using [1beta-3H]androstenedione after 1 hr by scintillation spectrometry
|
[PMID: 24900302] |
| JEG-3 | IC50 |
0.5 nM
Compound: 1
|
Inhibition of aromatase in JEG3 cell membrane
Inhibition of aromatase in JEG3 cell membrane
|
[PMID: 17580845] |
Chemical Information
-
No. CAS 148869-05-0
-
Appearance Solid
-
Peso molecular 354.20
-
Fòrmula C16H12BrN5
-
Color Off-white to light yellow
-
SMILES
BrC(C=C1)=CC=C1CN(N2C=NN=C2)C3=CC=C(C#N)C=C3
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 250 mg/mL (705.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8233 mL | 14.1163 mL | 28.2326 mL | 70.5816 mL |
| 5 mM | 0.5647 mL | 2.8233 mL | 5.6465 mL | 14.1163 mL | |
| 10 mM | 0.2823 mL | 1.4116 mL | 2.8233 mL | 7.0582 mL | |
| 15 mM | 0.1882 mL | 0.9411 mL | 1.8822 mL | 4.7054 mL | |
| 20 mM | 0.1412 mL | 0.7058 mL | 1.4116 mL | 3.5291 mL | |
| 25 mM | 0.1129 mL | 0.5647 mL | 1.1293 mL | 2.8233 mL | |
| 30 mM | 0.0941 mL | 0.4705 mL | 0.9411 mL | 2.3527 mL | |
| 40 mM | 0.0706 mL | 0.3529 mL | 0.7058 mL | 1.7645 mL | |
| 50 mM | 0.0565 mL | 0.2823 mL | 0.5647 mL | 1.4116 mL | |
| 60 mM | 0.0471 mL | 0.2353 mL | 0.4705 mL | 1.1764 mL | |
| 80 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8823 mL | |
| 100 mM | 0.0282 mL | 0.1412 mL | 0.2823 mL | 0.7058 mL |
YM511 Related Classifications
HY-105184 Related Classifications
Powered by Bioz