IL18BP - interleukin 18 binding protein Gene

Also Known as FVH; IL18BPa

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10068

About IL18BP

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,998,909-72,008,200 (from NCBI)

This gene has 18 transcripts (splice variants), 89 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues.

Summary

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18BP Products (7)

mRNA Protein Name
NM_001039659.2 NP_001034748.1 interleukin-18-binding protein isoform a precursor
NM_001039660.2 NP_001034749.1 interleukin-18-binding protein isoform a precursor
NM_001145055.1 NP_001138527.1 interleukin-18-binding protein isoform b precursor
NM_001145057.1 NP_001138529.1 interleukin-18-binding protein isoform a precursor
NM_005699.3 NP_005690.2 interleukin-18-binding protein isoform c precursor
NM_173042.2 NP_766630.2 interleukin-18-binding protein isoform a precursor
NM_173044.3 NP_766632.2 interleukin-18-binding protein isoform d precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables interleukin-18 binding IDA
IDA: Inferred from direct assay
10023777 GOA
Biological Process GO Annotation Evidence References Source
involved in T-helper 1 type immune response IDA
IDA: Inferred from direct assay
10023777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18-binding protein

  • MC51L-53L-54L homolog gene product

Recombinant IL18BP Proteins

Cat. No. Product Name Accession Purity
HY-P7211 IL-18BP Protein, Human (CHO) O95998-2 (T31-G194) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72575 IL-18BP Protein, Human (HEK293, hFc) AAD17187.1 (T29-G192) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P77709 IL-18BP Protein, Human (HEK293, His) O95998-2 (T31-G194) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78156 IL-18BP Protein, Human (Biotinylated, HEK293, His-Avi) O95998-2 (T31-G194) ≥ 95%, as determined by Bis-Tris PAGE.

IL18BP Antibodies

Cat. No. Product Name Application Reactivity
HY-P810786 IL18BP Antibody (YA10029) WB, IHC-P Human, Rat
HY-P85579 IL18BP Antibody (YA5271) WB Human

Related Diseases

Diseases Alias
Hepatitis, Fulminant Viral

  • Hepatitis, Fulminant Viral, Susceptibility To

  • FVH

  • Fulminant Viral Hepatitis

  • {Hepatitis, Fulminant Viral, Susceptibility To}
Molluscum Contagiosum

  • Water Warts

  • Molluscum Verrucosum
Cowpox

  • Yaba
Viral Hepatitis

  • Animal Viral Hepatitis

  • Hepatitis, Viral, Animal

  • Human Viral Hepatitis

  • Viral Hepatitis With Hepatic Coma
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Adult-Onset Still'S Disease

  • Adult-Onset Still Disease

  • Adult Onset Still'S Disease

  • Adult Still'S Disease

  • Still'S Disease Adult Onset

  • Aosd

  • Wissler-Fanconi Syndrome

  • Stills Disease Adult-Onset

  • Still'S Disease, Adult-Onset

  • Wissler'S Syndrome
Smallpox

  • Variola

  • Ordinary Smallpox

  • Alastrim

  • Amaas
Toxic Optic Neuropathy
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Hemophagocytic Lymphohistiocytosis

  • Lymphohistiocytosis, Hemophagocytic

  • Haemophagocytic Syndrome

  • Lymphohistiocytosis Hemophagocytic

  • Hemophagocytic Syndrome

  • Familial Hemophagocytic Lymphocytosis

  • Histiocytoses Of Mononuclear Phagocytes

  • Haemophagocytic Lymphohistiocytosis Nos
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-102019 NSC61610 Inhibitor 99.89% Unkown
HY-160793 NSC80734 Inhibitor 98.08% Unkown
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18310 Il18bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24788 Il18bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992335 COM503 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL18BP MGD MGI:1333800
Canis familiaris IL18BP VGNC VGNC:41952
Rattus norvegicus IL18BP RGD RGD:620042
Macaca mulatta IL18BP VGNC VGNC:73713
Bos taurus IL18BP VGNC VGNC:54438
Felis catus IL18BP VGNC VGNC:82043
Others IL18BP NCBI