Kdm6a - lysine demethylase 6A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 103689969

Summary

Predicted to enable DNA binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and identical protein binding activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and histone H3-K27 demethylation. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system Cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast Cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm6a Products (14)

mRNA Protein Name
XM_039100369.1 XP_038956297.1 lysine-specific demethylase 6A isoform X10
XM_039100366.1 XP_038956294.1 lysine-specific demethylase 6A isoform X7
XM_039100363.1 XP_038956291.1 lysine-specific demethylase 6A isoform X4
XM_039100368.1 XP_038956296.1 lysine-specific demethylase 6A isoform X9
XM_039100364.1 XP_038956292.1 lysine-specific demethylase 6A isoform X5
XM_039100362.1 XP_038956290.1 lysine-specific demethylase 6A isoform X3
XM_039100360.1 XP_038956288.1 lysine-specific demethylase 6A isoform X2
XM_039100359.1 XP_038956287.1 lysine-specific demethylase 6A isoform X1
XM_039100373.1 XP_038956301.1 lysine-specific demethylase 6A isoform X14
XM_039100372.1 XP_038956300.1 lysine-specific demethylase 6A isoform X13
XM_039100371.1 XP_038956299.1 lysine-specific demethylase 6A isoform X12
XM_039100370.1 XP_038956298.1 lysine-specific demethylase 6A isoform X11
XM_039100367.1 XP_038956295.1 lysine-specific demethylase 6A isoform X8
XM_039100365.1 XP_038956293.1 lysine-specific demethylase 6A isoform X6

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
27722168 RGD
involved in cellular response to endothelin IEP
IEP: Inferred from expression pattern
27722168 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
30887465 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
31266808 RGD
involved in cellular response to vitamin D IDA
IDA: Inferred from direct assay
31907922 RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
30887465 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
31266808 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
30887465 RGD
involved in protein modification process IMP
IMP: Inferred from mutant phenotype
30887465 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33075501 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 6A

  • lysine (K)-specific demethylase 6A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15648B GSK-J4 99.67% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-138794 XL177A Inhibitor 99.60% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-15648A GSK-J2 Control 99.75% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.33% Unkown
HY-138794A (Rac)-XL177A Inhibitor / Unkown
HY-RS07222 KDM6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-138794G XL177A (GMP) Inhibitor / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS16705 Kdm6a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23140 Kdm6a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24089 Uty Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm6a NCBI NCBI:7403