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LRRC41 - leucine rich repeat containing 41 Gene

Also Known as MUF1; PP7759

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10489

About LRRC41

Cytogenetic location: 1p34.1-p33 Genomic coordinates (GRCh38): 1:46,277,462-46,303,616 (from NCBI)

This gene has 7 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in thyroid (RPKM 20.0), ovary (RPKM 19.8) and 25 other tissues.

Summary

Predicted to enable identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRC41 Products (1)

mRNA	Protein	Name
NM_006369.5	NP_006360.3	leucine-rich repeat-containing protein 41

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leucine-rich repeat-containing protein 41	MUF1 protein (MUF1)

LRRC41 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRRC41	Q15345	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Validated Y2H	32296183
Intra	LRRC41	Q15345	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	LRRC41	Q15345	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	LRRC41	Q15345	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	LRRC41	Q15345	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Xia-Gibbs Syndrome	Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome XIGIS Mrd25 Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome Mental Retardation, Autosomal Dominant 25, Formerly Mrd25, Formerly Autosomal Dominant Mental Retardation 25 Autosomal Dominant Intellectual Disability 25 Xgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-183078	P6620	Inhibitor	/	Unkown
HY-RS07819	LRRC41 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRC41	VGNC	VGNC:63299
Mus musculus	LRRC41	MGD	MGI:2441984
Rattus norvegicus	LRRC41	RGD	RGD:1311221
Macaca mulatta	LRRC41	VGNC	VGNC:100000
Canis familiaris	LRRC41	VGNC	VGNC:42798
Others	LRRC41	NCBI