Sharpin - SHANK-associated RH domain interacting protein Gene

Also Known as cpdm; SIPL1; RBCKL1; 0610041B22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106025

Summary

Predicted to enable several functions, including identical protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Predicted to be located in cytosol; dendrite; and postsynaptic density. Predicted to be part of LUBAC complex. Is expressed in genitourinary system. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor). [provided by Alliance of Genome Resources, Apr 2022]

Sharpin Products (1)

mRNA Protein Name
NM_025340.2 NP_079616.2 sharpin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20956555 MGI
enables protein-macromolecule adaptor activity IMP
IMP: Inferred from mutant phenotype
34755089 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic nuclear changes IMP
IMP: Inferred from mutant phenotype
7792947 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
7792947 MGI
acts upstream of or within keratinization IMP
IMP: Inferred from mutant phenotype
7792947 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
7792947 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21455173 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21455173 MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21455173 MGI
Cellular Component GO Annotation Evidence References Source
part of LUBAC complex IDA
IDA: Inferred from direct assay
34755089 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sharpin

  • mSIPL1

  • protein kinase C-interacting protein RBCC like 1

  • shank-associated RH domain-interacting protein

  • shank-interacting protein-like 1

Sharpin Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sharpin Q91WA6 Eya1 Mus musculus P97767
Pull Down
20956555
Intra
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455181
Intra
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455180
Intra
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
23942237
Intra
Sharpin Q91WA6 Eya2 Mus musculus O08575
Y2H
20956555
Intra
Sharpin Q91WA6 Eya2 Mus musculus O08575
Pull Down
20956555
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12853 SHARPIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19284 Sharpin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25774 Sharpin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sharpin NCBI NCBI:81858