IGF2BP2 - insulin like growth factor 2 mRNA binding protein 2 Gene

Also Known as IMP2; IMP-2; VICKZ2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10644

About IGF2BP2

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,643,130-185,825,042 (from NCBI)

This gene has 11 transcripts (splice variants), 222 orthologues, 12 paralogues and is associated with 64 phenotypes. Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues.

Summary

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

IGF2BP2 Products (7)

mRNA	Protein	Name
NM_001007225.3	NP_001007226.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform b
NM_001291869.3	NP_001278798.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform c
NM_001291872.3	NP_001278801.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform d
NM_001291873.3	NP_001278802.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform e
NM_001291874.3	NP_001278803.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform f
NM_001291875.3	NP_001278804.1	insulin-like growth factor 2 mRNA-binding protein 2 isoform g
NM_006548.6	NP_006539.3	insulin-like growth factor 2 mRNA-binding protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	29476152	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	20080952	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	9891060	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12674497	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	29476152	GOA
involved in RNA stabilization	IMP IMP: Inferred from mutant phenotype	36354136	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	29476152	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15618018	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	29476152	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	15618018	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15618018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGF2BP2 Protein Structure

RRM_1

KH_1

0
100
200
300
400
500
599 a.a.

Protein Preferred Names	Protein Names
insulin-like growth factor 2 mRNA-binding protein 2	IGF-II mRNA-binding protein 2

IGF2BP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGF2BP2	Q9Y6M1	DYRK1A	Homo sapiens	Q13627	Anti Bait CoIP	36950384
Intra	IGF2BP2	Q9Y6M1	RBM3	Homo sapiens	P98179	Anti Bait CoIP	31484925
Intra	IGF2BP2	Q9Y6M1	RBM3	Homo sapiens	P98179	Anti Tag CoIP	31484925
Intra	IGF2BP2	Q9Y6M1	HNRNPD	Homo sapiens	Q14103-4	Pull Down	12674497

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGF2BP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70950	IGF2BP2 Protein, Human (T7-His)	Q9Y6M1-2 (M1-T220)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74850	IGF2BP2 Protein, Human (sf9, His-GST)	Q9Y6M1-2 (M1-K599)	≥ 95%, as determined by reducing SDS-PAGE.

IGF2BP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82288	IGF2BP2 Antibody (YA2033)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82288A	IGF2BP2 Antibody (YA2033)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Diabetes Mellitus	Diabetes
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153274	CWI1-2	Inducer	98.85%	Unkown
HY-153274A	CWI1-2 hydrochloride	Inducer	98.27%	Unkown
HY-RS06620	IGF2BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181666	Z971169476		/	Unkown
HY-RS16822	Igf2bp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23262	Igf2bp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IGF2BP2	MGD	MGI:1890358
Felis catus	IGF2BP2	VGNC	VGNC:62889
Macaca mulatta	IGF2BP2	VGNC	VGNC:84165
Canis familiaris	IGF2BP2	VGNC	VGNC:41899
Bos taurus	IGF2BP2	VGNC	VGNC:30080
Rattus norvegicus	IGF2BP2	RGD	RGD:1305614
Others	IGF2BP2	NCBI