TUBGCP2 - tubulin gamma complex associated protein 2 Gene

Also Known as ALP4; GCP2; GCP-2; SPC97; h103p; hGCP2; SPBC97; Spc97p; hSpc97; Grip103; PAMDDFS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10844

About TUBGCP2

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,278,635-133,312,337 (from NCBI)

This gene has 35 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 14.0), kidney (RPKM 12.2) and 25 other tissues.

Summary

Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TUBGCP2 Products (3)

mRNA Protein Name
NM_001256617.2 NP_001243546.1 gamma-tubulin complex component 2 isoform 1
NM_001256618.2 NP_001243547.1 gamma-tubulin complex component 2 isoform 3
NM_006659.4 NP_006650.1 gamma-tubulin complex component 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16980960 GOA
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
31630790 GOA
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
31630790 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in microtubule organizing center IDA
IDA: Inferred from direct assay
9566967 GOA
located in microtubule organizing center IMP
IMP: Inferred from mutant phenotype
31630790 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUBGCP2 Protein Structure

Spc97_Spc98

Spc97_Spc98: Spc97 / Spc98 family (220 - 738)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
Protein Preferred Names Protein Names

gamma-tubulin complex component 2

  • gamma-ring complex protein 103 kDa

TUBGCP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TUBGCP2 Q9BSJ2 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra
TUBGCP2 Q9BSJ2 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra
TUBGCP2 Q9BSJ2 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pachygyria, Microcephaly, Developmental Delay, And Dysmorphic Facies, With Or Without Seizures

  • PAMDDFS
Neuronal Migration Disorders

  • Abnormality Of Neuronal Migration

  • Malformations Of Cortical Development, Group Ii

  • Neuronal Dysmigration Syndromes
Band Heterotopia

  • Subcortical Band Heterotopia

  • Double Cortex Syndrome

  • Subcortical Laminar Heterotopia

  • Double Cortex

  • Band Heterotopia Of Brain

  • BH

  • Heco

  • Heterotopic Cortex

  • Familial Band Heterotopia

  • Dc

  • Dc Syndrome

  • Heterotopia, Subcortical Band

  • Sbh

  • Sclh

  • Bhy
Streptococcal Meningitis
Chromosome 22q11.2 Duplication Syndrome

  • Chromosome 22q11.2 Microduplication Syndrome

  • 22q11.2 Microduplication Syndrome

  • 22q11.2 Duplication Syndrome

  • Duplication 22q11.2

  • Trisomy 22q11.2

  • 22q11.2 Duplication

  • Dup(22)(Q11)
Chromosome 15q11.2 Deletion Syndrome

  • 15q11.2 Microdeletion Syndrome

  • 15q11.2 Bp1-Bp2 Microdeletion Syndrome

  • Del(15)(Q11.2)

  • Monosomy 15q11.2

  • 15q11.2 Microdeletion

  • Chromosome 15q11.2 Deletion

  • Chromosome 15q11.2 Microdeletion

  • Chromosome Deletion Syndrome 15q11.2

  • Microdeletion 15q11.2

  • Duplication 15q11-Q13 Syndrome
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Diamond-Blackfan Anemia 1

  • Aase Syndrome

  • DBA1

  • Erythrogenesis Imperfecta

  • Aase-Smith Syndrome Ii

  • Dba

  • Blackfan-Diamond Syndrome

  • Bds

  • Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

  • Anemia, Congenital Erythroid Hypoplastic

  • Red Cell Aplasia, Pure, Hereditary

  • Aregenerative Anemia, Chronic Congenital

  • Rps19-Related Diamond-Blackfan Anemia

  • Chronic Congenital Aregenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Diamond-Blackfan, Type 1

  • Anemia, Diamond-Blackfan

  • Aase Smith Syndrome 2

  • Familial Hypoplastic Anaemia With Malformations

  • Constitutional Pure Red Cell Aplasia
Autoimmune Lymphoproliferative Syndrome

  • ALPS

  • Canale-Smith Syndrome

  • Autoimmune Lymphoproliferative Syndrome, Type Ia

  • Autoimmune Lymphoproliferative Syndrome, Type Ib

  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

  • Css

  • Autoimmune Lymphoproliferative Syndrome, Type 1b

  • Autoimmune Lymphoproliferative Syndrome, Type 1a

  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

  • Fas Deficiency

  • Autoimmune Lymphoproliferative Syndrome 1a

  • ALPS1A

  • Autoimmune Lymphoproliferative Syndrome Type Ia

  • Autoimmune Lymphoproliferative Syndrome 1b

  • ALPS1B

  • Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15262 TUBGCP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TUBGCP2 RGD RGD:1309597
Bos taurus TUBGCP2 VGNC VGNC:36512
Mus musculus TUBGCP2 MGD MGI:1921487
Felis catus TUBGCP2 VGNC VGNC:66704
Macaca mulatta TUBGCP2 VGNC VGNC:79154
Canis familiaris TUBGCP2 VGNC VGNC:53016
Others TUBGCP2 NCBI