TCERG1 - transcription elongation regulator 1 Gene

Also Known as Urn1; CA150; TAF2S

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10915

About TCERG1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,447,330-146,511,961 (from NCBI)

This gene has 17 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TCERG1 Products (16)

mRNA Protein Name
NM_001040006.2 NP_001035095.1 transcription elongation regulator 1 isoform 2
NM_001382548.1 NP_001369477.1 transcription elongation regulator 1 isoform 3
NM_001400077.1 NP_001387006.1 transcription elongation regulator 1 isoform 4
NM_001400082.1 NP_001387011.1 transcription elongation regulator 1 isoform 5
NM_001400083.1 NP_001387012.1 transcription elongation regulator 1 isoform 6
NM_001400084.1 NP_001387013.1 transcription elongation regulator 1 isoform 7
NM_001400085.1 NP_001387014.1 transcription elongation regulator 1 isoform 8
NM_001400092.1 NP_001387021.1 transcription elongation regulator 1 isoform 9
NM_001400093.1 NP_001387022.1 transcription elongation regulator 1 isoform 10
NM_001400094.1 NP_001387023.1 transcription elongation regulator 1 isoform 11
NM_001400095.1 NP_001387024.1 transcription elongation regulator 1 isoform 16
NM_001400096.1 NP_001387025.1 transcription elongation regulator 1 isoform 12
NM_001400097.1 NP_001387026.1 transcription elongation regulator 1 isoform 13
NM_001400098.1 NP_001387027.1 transcription elongation regulator 1 isoform 14
NM_001400099.1 NP_001387028.1 transcription elongation regulator 1 isoform 15
NM_006706.4 NP_006697.2 transcription elongation regulator 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20956529 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17060612 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
20956529 GOA
enables ubiquitin-like protein conjugating enzyme binding IPI
IPI: Inferred from physical interaction
20215116 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA splicing IDA
IDA: Inferred from direct assay
20215116 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
20215116 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20956529 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20215116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCERG1 Protein Structure

WW

WW: WW domain (137 - 162)

WW

WW: WW domain (434 - 460)

FF

FF: FF domain (663 - 709)

FF

FF: FF domain (727 - 776)

FF

FF: FF domain (794 - 843)

FF

FF: FF domain (898 - 949)

FF

FF: FF domain (956 - 1007)

FF

FF: FF domain (1015 - 1074)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1098 a.a.
Protein Preferred Names Protein Names

transcription elongation regulator 1

  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD

TCERG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TCERG1 O14776 HTT Homo sapiens P42858
Y2H
17500595
Intra
TCERG1 O14776 HTT Homo sapiens P42858
Y2H
15383276
Intra
TCERG1 O14776 TCERG1 Homo sapiens O14776
Fluorescence Spectr
17060612
Intra
TCERG1 O14776 TCERG1 Homo sapiens O14776
TEM
17060612
Intra
TCERG1 O14776 TCERG1 Homo sapiens O14776
Solid State NMR
17060612
Intra
TCERG1 O14776 TCERG1 Homo sapiens O14776
Light Scattering
17060612
Intra
TCERG1 O14776 Dlg4 Rattus norvegicus P31016
Peptide Array
20467438
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14297 TCERG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14298 TCERG1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TCERG1 VGNC VGNC:47188
Rattus norvegicus TCERG1 RGD RGD:1311748
Macaca mulatta TCERG1 VGNC VGNC:78389
Bos taurus TCERG1 VGNC VGNC:35685
Felis catus TCERG1 VGNC VGNC:66020
Mus musculus TCERG1 MGD MGI:1926421
Others TCERG1 NCBI