MTFR2 - mitochondrial fission regulator 2 Gene

Also Known as DUFD1; FAM54A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113115

About MTFR2

This gene has 7 transcripts (splice variants), 190 orthologues and 2 paralogues. Biased expression in testis (RPKM 2.0), bone marrow (RPKM 1.8) and 12 other tissues.

Summary

Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MTFR2 Products (3)

mRNA Protein Name
NM_001099286.3 NP_001092756.1 mitochondrial fission regulator 2 isoform a
NM_001318738.2 NP_001305667.1 mitochondrial fission regulator 2 isoform b
NM_138419.5 NP_612428.2 mitochondrial fission regulator 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTFR2 Protein Structure

Mito_fiss_reg

Mito_fiss_reg: Mitochondrial fission regulator (23 - 286)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

mitochondrial fission regulator 2

  • DUF729 domain-containing protein 1

MTFR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTFR2 Q6P444 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
MTFR2 Q6P444 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra
MTFR2 Q6P444 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra
MTFR2 Q6P444 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Intra
MTFR2 Q6P444 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
MTFR2 Q6P444 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
MTFR2 Q6P444 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra
MTFR2 Q6P444 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Suppurative Periapical Periodontitis

  • Periapical Abscess

  • Apical Abscess

  • Suppurative Apical Periodontitis

  • Dentoalveolar Abscess

  • Dental Abscess With Sinus

  • Dentoalveolar Abscess With Sinus

  • Dental Sinus

  • Periapical Abscess Fistula

  • Apical Tooth Abscess

  • Apex Abscess

  • Dental Abscess Nos

  • Infection Of Tooth Nos

  • Abscess Of Tooth

  • Dental Infection Nos
Lung Acinar Adenocarcinoma

  • Acinar Adenocarcinoma Of The Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08771 MTFR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MTFR2 VGNC VGNC:82491
Macaca mulatta MTFR2 VGNC VGNC:74999
Mus musculus MTFR2 MGD MGI:1919054
Bos taurus MTFR2 VGNC VGNC:31728
Rattus norvegicus MTFR2 RGD RGD:6494892
Canis familiaris MTFR2 VGNC VGNC:43470
Others MTFR2 NCBI