PDAP1 - PDGFA associated protein 1 Gene

Also Known as PAP; PAP1; HASPP28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11333

About PDAP1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,394,673-99,408,597 (from NCBI)

This gene has 5 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in fat (RPKM 24.9), colon (RPKM 23.3) and 25 other tissues.

Summary

The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

PDAP1 Products (1)

mRNA Protein Name
NM_014891.7 NP_055706.1 28 kDa heat- and acid-stable phosphoprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDAP1 Protein Structure

PP28

PP28: Casein kinase substrate phosphoprotein PP28 (84 - 164)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

28 kDa heat- and acid-stable phosphoprotein

  • PDGF-associated protein

PDAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDAP1 Q13442 PELI1 Homo sapiens Q96FA3
Validated Y2H
32296183
Intra
PDAP1 Q13442 KLHL36 Homo sapiens Q8N4N3
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71186 PAP Protein, Human (His) Q13442 (M1-K181) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10183 PDAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18539 Pdap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25021 Pdap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PDAP1 VGNC VGNC:32655
Felis catus PDAP1 VGNC VGNC:64076
Canis familiaris PDAP1 VGNC VGNC:44332
Rattus norvegicus PDAP1 RGD RGD:620442
Macaca mulatta PDAP1 VGNC VGNC:75604
Mus musculus PDAP1 MGD MGI:2448536
Others PDAP1 NCBI