Abl2 - v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Gene

Also Known as Arg; Abll

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11352

Summary

Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in actin Cytoskeleton organization; peptidyl-tyrosine phosphorylation; and synapse maturation. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse. Is expressed in several structures, including brain; diaphragm; hindlimb long bone; liver; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl2 Products (2)

mRNA Protein Name
NM_001136104.1 NP_001129576.1 tyrosine-protein kinase ABL2 isoform a
NM_009595.3 NP_033725.2 tyrosine-protein kinase ABL2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12748290 MGI
enables manganese ion binding IDA
IDA: Inferred from direct assay
12748290 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19414610 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12748290 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
18827006 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
15084284 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Bergmann glial cell differentiation IGI
IGI: Inferred from genetic interaction
20980600 MGI
acts upstream of or within DN4 thymocyte differentiation IGI
IGI: Inferred from genetic interaction
18025176 MGI
acts upstream of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
23595732 MGI
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
11752434 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within actin filament bundle assembly IDA
IDA: Inferred from direct assay
11752434 MGI
acts upstream of or within actin filament organization IDA
IDA: Inferred from direct assay
11752434 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of or within aggressive behavior IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of or within alpha-beta T cell differentiation IGI
IGI: Inferred from genetic interaction
18025176 MGI
acts upstream of or within auditory behavior IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
18025176 MGI
acts upstream of cell-cell adhesion IGI
IGI: Inferred from genetic interaction
24367707 MGI
acts upstream of or within cerebellum morphogenesis IGI
IGI: Inferred from genetic interaction
20980600 MGI
acts upstream of or within circulatory system development IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
22357865 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23365224 MGI
acts upstream of or within dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
23365224 MGI
acts upstream of or within dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
23365224 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18827006 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
23100514 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
22665498 MGI
acts upstream of or within exploration behavior IGI
IGI: Inferred from genetic interaction
23595732 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
19805386 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IGI
IGI: Inferred from genetic interaction
15084284 MGI
acts upstream of or within negative regulation of cell-cell adhesion IGI
IGI: Inferred from genetic interaction
24367707 MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process IGI
IGI: Inferred from genetic interaction
23840065 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within neuroepithelial cell differentiation IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
20980600 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within neuron remodeling IMP
IMP: Inferred from mutant phenotype
19805386 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12748290 MGI
acts upstream of or within phagocytosis IGI
IGI: Inferred from genetic interaction
23100514 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
22665498 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18827006 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
18827006 MGI
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
22810897 MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
20837657 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
18025176 MGI
involved in positive regulation of establishment of T cell polarity IMP
IMP: Inferred from mutant phenotype
22810897 MGI
acts upstream of or within positive regulation of interleukin-2 production IGI
IGI: Inferred from genetic interaction
18025176 MGI
acts upstream of or within positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
15084284 MGI
acts upstream of or within positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
15084284 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
18025176 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
9883720 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
23365224 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12748290 MGI
acts upstream of or within regulation of extracellular matrix organization IGI
IGI: Inferred from genetic interaction
20980600 MGI
acts upstream of or within reproductive process IMP
IMP: Inferred from mutant phenotype
9883720 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: Inferred from genetic interaction
19414610 MGI
involved in synapse maturation IDA
IDA: Inferred from direct assay
27335408 MGI
involved in synapse maturation IMP
IMP: Inferred from mutant phenotype
27335408 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
22357865 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11752434 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
23365224 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23365224 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23365224 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
19414610 MGI
located in phagocytic cup IDA
IDA: Inferred from direct assay
23100514 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
23365224 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
23365224 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase ABL2

  • Abelson tyrosine-protein kinase 2

  • Abelson-related gene protein

  • abelson murine leukemia viral oncogene homolog 2

  • tyrosine kinase ARG

  • tyrosine-protein kinase ARG

  • v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-178382 BRAFV600E/ABL2-IN-1 / Unkown
HY-181726 BRAFV600E/ABL2-IN-2 / Unkown
HY-182792 Embibatinib Inhibitor / Unkown
HY-RS00105 ABL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18744 Abl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25231 Abl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abl2 NCBI NCBI:27