Acox1 - acyl-Coenzyme A oxidase 1, palmitoyl Gene

Also Known as AOX; Acox; Paox; D130055E20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11430

Summary

This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Acox1 Products (5)

mRNA Protein Name
NM_001271898.2 NP_001258827.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 2
NM_001377521.1 NP_001364450.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 3
NM_001377522.1 NP_001364451.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 4
NM_015729.4 NP_056544.2 peroxisomal acyl-coenzyme A oxidase 1 isoform 1
NM_001377521.1 NP_001364450.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
20195242 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
8798738 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11156684 MGI
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
12915479 MGI
located in peroxisome IDA
IDA: Inferred from direct assay
17881773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxisomal acyl-coenzyme A oxidase 1

  • palmitoyl-CoA oxidase

  • peroxisomal fatty acyl-CoA oxidase

  • peroxisomal fatty acyl-coenzyme A oxidase

  • peroxisomal straight-chain Acyl-CoA oxidase

  • straight-chain acyl-CoA oxidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135425 10,12-Tricosadiynoic acid Inhibitor 99.95% Unkown
HY-N1966 (E)-Osmundacetone 99.81% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-RS00182 ACOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17057 Acox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23501 Acox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acox1 NCBI NCBI:51