C1QTNF4 - C1q and TNF related 4 Gene

Also Known as CTRP4; ZACRP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114900

About C1QTNF4

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,589,667-47,595,304 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 173 orthologues and 23 paralogues. Biased expression in brain (RPKM 5.9), bone marrow (RPKM 0.3) and 2 other tissues.

Summary

Predicted to enable cytokine activity. Involved in positive regulation of cytokine production and positive regulation of signal transduction. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF4 Products (1)

mRNA Protein Name
NM_031909.3 NP_114115.2 complement C1q tumor necrosis factor-related protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
21658842 GOA
involved in positive regulation of interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
21658842 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
21658842 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
21658842 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21658842 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF4 Protein Structure

C1q

C1q: C1q domain (31 - 156)

C1q

C1q: C1q domain (178 - 311)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

complement C1q tumor necrosis factor-related protein 4

  • C1q and tumor necrosis factor related protein 4

C1QTNF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
C1QTNF4 Q9BXJ3 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
C1QTNF4 Q9BXJ3 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
C1QTNF4 Q9BXJ3 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
C1QTNF4 Q9BXJ3 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
C1QTNF4 Q9BXJ3 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01730 C1QTNF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus C1QTNF4 RGD RGD:1311006
Mus musculus C1QTNF4 MGD MGI:1914695
Macaca mulatta C1QTNF4 VGNC VGNC:70313
Canis familiaris C1QTNF4 VGNC VGNC:51856
Felis catus C1QTNF4 VGNC VGNC:81910
Others C1QTNF4 NCBI