Sh3gl2 - SH3 domain containing GRB2 like 2, endophilin A1 Gene

Also Known as Sh3p4; Sh3d2a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116743

Summary

Enables several functions, including identical protein binding activity; protein C-terminus binding activity; and protein kinase binding activity. Involved in several processes, including lipid tube assembly; positive regulation of membrane tubulation; and vesicle scission. Located in several cellular components, including basal dendrite; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and synaptic vesicle membrane. Biomarker of visual epilepsy. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl2 Products (1)

mRNA Protein Name
NM_053935.1 NP_446387.1 endophilin-A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
24568626 RGD
enables lipid binding IDA
IDA: Inferred from direct assay
11604418 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9238017 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
11384986 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
22961472 RGD
Biological Process GO Annotation Evidence References Source
involved in lipid tube assembly IDA
IDA: Inferred from direct assay
20484046 RGD
involved in membrane bending IMP
IMP: Inferred from mutant phenotype
16763559 RGD
involved in membrane tubulation IDA
IDA: Inferred from direct assay
20484046 RGD
involved in membrane tubulation IMP
IMP: Inferred from mutant phenotype
11604418 RGD
involved in positive regulation of membrane tubulation IMP
IMP: Inferred from mutant phenotype
24778241 RGD
involved in regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
15066995 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
22099461 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
22099461 RGD
involved in vesicle scission IDA
IDA: Inferred from direct assay
11604418 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11518713 RGD
located in basal dendrite IDA
IDA: Inferred from direct assay
14751282 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17088211 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11518713 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
14751282 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14751282 RGD
located in presynapse IDA
IDA: Inferred from direct assay
11518713 RGD
is active in synapse IDA
IDA: Inferred from direct assay
11518713 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
17088211 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endophilin-A1

  • SH3 domain protein 2A

  • SH3 domain-containing GRB2-like 2

  • SH3 domain-containing GRB2-like protein 2

  • SH3-domain GRB2-like 2

  • endophilin-1

Sh3gl2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh3gl2 O35179 Synj1 Rattus norvegicus Q62910
Pull Down
9238017
Intra
Sh3gl2 O35179 Synj1 Rattus norvegicus Q62910
Far-WB
9238017
Intra
Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Anti Bait CoIP
17437541
Intra
Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Pull Down
16221862
Intra
Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Far-WB
9238017
Intra
Sh3gl2 O35179 Dnm1 Rattus norvegicus P21575
Pull Down
9238017
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12837 SH3GL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3gl2 NCBI NCBI:6456