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Dnm1 - dynamin 1 Gene

Also Known as Dnm

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 140694

Summary

Enables several functions, including D2 Dopamine Receptor binding activity; SH3 domain binding activity; and nitric-oxide synthase binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in several cellular components, including Golgi apparatus; synaptic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31. Orthologous to human DNM1 (Dynamin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnm1 Products (1)

mRNA	Protein	Name
NM_080689.5	NP_542420.1	dynamin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D2 dopamine receptor binding	IPI IPI: Inferred from physical interaction	14709338	RGD
enables SH3 domain binding	IDA IDA: Inferred from direct assay	16648848	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	9348539	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16432212	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	21490139	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9238017	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17257598	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9348539	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	14709338	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	17437541	RGD
involved in positive regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	17880892	RGD
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	11100149	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	12011079	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	16648848	RGD
involved in response to amyloid-beta	IEP IEP: Inferred from expression pattern	20847448	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	9725914	RGD
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	9725914	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	17257598	RGD
located in presynapse	IDA IDA: Inferred from direct assay	9238017	RGD
is active in presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	7877693	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17257598	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	12646135	RGD
located in varicosity	IDA IDA: Inferred from direct assay	12646135	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynamin-1	B-dynamin D100 dynamin, brain

Dnm1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Anti Bait CoIP	17437541
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Pull Down	17437541
Intra	Dnm1	P21575	Sh3gl2	Rattus norvegicus	O35179	Competition Binding	17437541
Intra	Dnm1	P21575	Pacsin1	Rattus norvegicus	Q9Z0W5	Competition Binding	17437541
Intra	Dnm1	P21575	Pacsin1	Rattus norvegicus	Q9Z0W5	Pull Down	17437541
Intra	Dnm1	P21575	Grb2	Rattus norvegicus	P62994	Competition Binding	17437541
Intra	Dnm1	P21575	Grb2	Rattus norvegicus	P62994	Pull Down	17437541
Cross	Dnm1	P21575	MYO1E	Homo sapiens	Q12965	Pull Down	17257598
Cross	Dnm1	P21575	MYO1E	Homo sapiens	Q12965	Anti Bait CoIP	17257598
Intra	Dnm1	P21575	Pik3r1	Rattus norvegicus	Q63787	Pull Down	17437541
Cross	Dnm1	P21575	q5tcz1-2	Homo sapiens	Q5TCZ1-2	ITC	19464300
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	TEM	21927001
Intra	Dnm1	P21575	Sorbs2	Rattus norvegicus	O35413	Anti Bait CoIP	19116150
Intra	Dnm1	P21575	Nckipsd	Mus musculus	Q9ESJ4	Pull Down	16221862
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	X-Ray Diffraction	21927001
Intra	Dnm1	P21575	Amph	Rattus norvegicus	O08838	Pull Down	17437541
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	GMS	21927001
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Density Sedimentation	21927001
Intra	Dnm1	P21575	Amph	Rattus norvegicus	O08838	Pull Down	9348539
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	TEM	16432212
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Light Scattering	21927001
Intra	Dnm1	P21575	Dnm1	Rattus norvegicus	P21575	Comigration in SDS	16432212
Intra	Dnm1	P21575	Nckipsd	Mus musculus	Q9ESJ4	Anti Bait CoIP	16221862
Intra	Dnm1	P21575	Bin1	Rattus norvegicus	O08839	Pull Down	9348539
Intra	Dnm1	P21575	Shank1	Rattus norvegicus	Q9WV48	Anti Tag CoIP	11583995
Intra	Dnm1	P21575	Shank1	Rattus norvegicus	Q9WV48	Anti Bait CoIP	11583995

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03904	DNM1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28663	Dnm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03903	DNM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17698	Dnm1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22142	Dnm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24160	Dnm1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm1	NCBI	NCBI:1759