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Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

Also Known as PI3KA

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25513

Summary

Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; Calmodulin binding activity; and enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of phosphorylation; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in neuron projection; nucleus; and plasma membrane. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial Cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pik3r1 Products (1)

mRNA	Protein	Name
NM_013005.2	NP_037137.2	phosphatidylinositol 3-kinase regulatory subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	20236230	RGD
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA IDA: Inferred from direct assay	12882977	RGD
enables ATPase binding	IPI IPI: Inferred from physical interaction	17728397	RGD
enables calmodulin binding	IPI IPI: Inferred from physical interaction	17492691	RGD
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	12891559	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	16971528	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	12882964	RGD
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	18421086	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10437794	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10973965	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15530849	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18292389	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14962484	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18773943	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	17593346	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18922131	RGD
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	9440811	RGD
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15161606	RGD
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9440811	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19015400	RGD
involved in negative regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15530849	RGD
involved in negative regulation of heart rate	IMP IMP: Inferred from mutant phenotype	19015400	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15089039	RGD
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	15161606	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19783773	RGD
involved in phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	12882977	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15530849	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20333648	RGD
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	9440811	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19723872	RGD
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	21414895	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	19106217	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	10875243	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	20032058	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19462258	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17622585	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19369057	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	17976658	RGD
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	15187100	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	18421086	RGD
involved in response to insulin	IDA IDA: Inferred from direct assay	16150536	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	17600839	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19657097	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	18752305	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	20032058	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20519555	RGD
involved in response to yeast	IEP IEP: Inferred from expression pattern	19958054	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of phosphatidylinositol 3-kinase complex	IDA IDA: Inferred from direct assay	12882977	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10973965	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase regulatory subunit alpha	PI3-kinase p85 subunit alpha PI3-kinase regulatory subunit alpha PI3-kinase subunit p85-alpha PI3K regulatory subunit alpha Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50) Phosphoinositide 3-kinase, regulatory subunit, polypeptid

Pik3r1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pik3r1	Q63787	Shtn1	Rattus norvegicus	A0MZ67	Anti Bait CoIP	17030985
Cross	Pik3r1	Q63787	PDE6G	Homo sapiens	P18545	Y2H	16357825
Intra	Pik3r1	Q63787	Khdrbs1	Rattus norvegicus	Q91V33	CoIP	10437794
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Filter Binding	16890252
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Anti Bait CoIP	16890252
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Pull Down	16890252

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6983	Licoricesaponin G2		99.87%	Unkown
HY-161366	OMS14	Inhibitor	99.09%	Unkown
HY-RS10536	PIK3R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18872	Pik3r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25363	Pik3r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3r1	NCBI	NCBI:5295