TAGAP - T cell activation RhoGTPase activating protein Gene

Homo sapiens

Also known as FKSG15; IDDM21; TAGAP1; ARHGAP47

Gene ID: 117289 | Gene type: protein coding

About TAGAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,034,481-159,044,991 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 44.8), lymph node (RPKM 19.7) and 10 other tissues.

Summary

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

TAGAP Products(4)

mRNA	Protein	Name
NM_001278733.2	NP_001265662.1	T-cell activation Rho GTPase-activating protein isoform d
NM_054114.5	NP_473455.2	T-cell activation Rho GTPase-activating protein isoform b
NM_138810.4	NP_620165.1	T-cell activation Rho GTPase-activating protein isoform c
NM_152133.3	NP_687034.1	T-cell activation Rho GTPase-activating protein isoform a

TAGAP Protein Structure

RhoGAP

0
200
400
600
731 a.a.

Protein Preferred Names

Protein Names

T-cell activation Rho GTPase-activating protein

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Febrile Seizures, Familial, 10

FEB10	Familial Febrile Seizures 10
Convulsions, Familial Febrile, 10	Familial Febrile Convulsions 10
Febrile Convulsions, Familial, 10

Candidal Paronychia

Candidiasis Of Skin	Candidiasis Of Skin And Nails
Candidal Perionyxis

Auditory Agnosia

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14185	TAGAP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TAGAP	VGNC	VGNC:65942
Bos taurus	TAGAP	VGNC	VGNC:35584
Rattus norvegicus	TAGAP	RGD	RGD:1308618
Mus musculus	TAGAP	MGD	MGI:1919786
Macaca mulatta	TAGAP	VGNC	VGNC:78126
Canis familiaris	TAGAP	VGNC	VGNC:47092

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