TAGAP - T cell activation RhoGTPase activating protein Gene

Also Known as FKSG15; IDDM21; TAGAP1; ARHGAP47

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 117289

About TAGAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,034,481-159,044,991 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 44.8), lymph node (RPKM 19.7) and 10 other tissues.

Summary

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

TAGAP Products (4)

mRNA Protein Name
NM_001278733.2 NP_001265662.1 T-cell activation Rho GTPase-activating protein isoform d
NM_054114.5 NP_473455.2 T-cell activation Rho GTPase-activating protein isoform b
NM_138810.4 NP_620165.1 T-cell activation Rho GTPase-activating protein isoform c
NM_152133.3 NP_687034.1 T-cell activation Rho GTPase-activating protein isoform a

TAGAP Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (101 - 246)

  • 0
  • 200
  • 400
  • 600
  • 731 a.a.
Protein Preferred Names Protein Names

T-cell activation Rho GTPase-activating protein

TAGAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TAGAP Q8N103 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TAGAP Q8N103 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TAGAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82396 TAGAP Antibody (YA2141) WB, IP Human, Rat
HY-P82396A TAGAP Antibody (YA2141)(PBS only) WB, IP Human, Rat
HY-P86294 TAGAP Antibody (YA5986) WB, FC, IP Human

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 21

  • Diabetes Mellitus, Insulin-Dependent, 21

  • Iddm21

  • T1D21

  • Insulin-Dependent Diabetes Mellitus 21
Febrile Seizures, Familial, 10

  • FEB10

  • Familial Febrile Seizures 10

  • Convulsions, Familial Febrile, 10

  • Familial Febrile Convulsions 10

  • Febrile Convulsions, Familial, 10
Candidal Paronychia

  • Candidiasis Of Skin

  • Candidiasis Of Skin And Nails

  • Candidal Perionyxis
Auditory Agnosia
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14185 TAGAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21060 Tagap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27577 Tagap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TAGAP VGNC VGNC:65942
Bos taurus TAGAP VGNC VGNC:35584
Rattus norvegicus TAGAP RGD RGD:1308618
Mus musculus TAGAP MGD MGI:1919786
Macaca mulatta TAGAP VGNC VGNC:78126
Canis familiaris TAGAP VGNC VGNC:47092
Others TAGAP NCBI