Nsmf - NMDA receptor synaptonuclear signaling and neuronal migration factor Gene

Also Known as Jac; Nelf; Jacob

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117536

Summary

Enables calcium-dependent protein binding activity. Involved in several processes, including cellular response to electrical stimulus; postsynapse to nucleus signaling pathway; and regulation of dendrite morphogenesis. Located in several cellular components, including dendrite; euchromatin; and nucleus. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 9 with or without anosmia. Orthologous to human NSMF (NMDA Receptor synaptonuclear signaling and neuronal migration factor). [provided by Alliance of Genome Resources, Apr 2022]

Nsmf Products (4)

mRNA Protein Name
NM_001270626.1 NP_001257555.1 NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 2
NM_001270627.1 NP_001257556.1 NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 3
NM_001270628.1 NP_001257557.1 NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 4
NM_057190.2 NP_476538.2 NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IDA
IDA: Inferred from direct assay
18303947 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18303947 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
18303947 RGD
involved in cellular response to electrical stimulus IDA
IDA: Inferred from direct assay
21364755 RGD
involved in postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
23452857 RGD
involved in postsynapse to nucleus signaling pathway IMP
IMP: Inferred from mutant phenotype
23452857 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18303947 RGD
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18303947 RGD
involved in regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18303947 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
21364755 RGD
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18303947 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18303947 RGD
located in euchromatin IDA
IDA: Inferred from direct assay
18303947 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18303947 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23452857 RGD
located in membrane IDA
IDA: Inferred from direct assay
18303947 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
18303947 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
18303947 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
18303947 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
21364755 RGD
located in nucleus IDA
IDA: Inferred from direct assay
18303947 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
21364755 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
18303947 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
18303947 RGD
located in synapse IDA
IDA: Inferred from direct assay
18303947 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NMDA receptor synaptonuclear signaling and neuronal migration factor

  • juxtasynaptic attractor of caldendrin on dendritic boutons protein

  • nasal embryonic LHRH factor

  • nasal embryonic luteinizing hormone-releasing hormone factor

Nsmf Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nsmf Q9EPI6 Ina Rattus norvegicus P23565
Pull Down
23452857
Intra
Nsmf Q9EPI6 Ina Rattus norvegicus P23565
Y2H
23452857
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09599 NSMF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsmf NCBI NCBI:26012