RLN3 - relaxin 3 Gene

Also Known as H3; RXN3; ZINS4; insl7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 117579

About RLN3

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,028,148-14,031,551 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 229 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the relaxin family of insulin-like Hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. The encoded protein is a precursor that is proteolytically processed to generate a heterodimeric mature form consisting A and B chains interlinked by disulfide bonds. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

RLN3 Products (2)

mRNA Protein Name
NM_001311197.2 NP_001298126.1 relaxin-3 precursor
NM_080864.4 NP_543140.1 relaxin-3 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24802387 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLN3 Protein Structure

Insulin

Insulin: Insulin/IGF/Relaxin family (33 - 142)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

relaxin-3

  • insulin-like peptide 7

RLN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RLN3 Q8WXF3 RXFP4 Homo sapiens Q8TDU9
Competition Binding
24802387
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12011 RLN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RLN3 MGD MGI:2158015
Felis catus RLN3 VGNC VGNC:64648
Rattus norvegicus RLN3 RGD RGD:628745
Bos taurus RLN3 VGNC VGNC:33991
Others RLN3 NCBI