RXFP4 - relaxin family peptide/INSL5 receptor 4 Gene

Also Known as GPR100; RLN3R2; RXFPR4; GPCR142

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339403

About RXFP4

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,941,638-155,943,087 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues and 7 paralogues.

Summary

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

RXFP4 Products (1)

mRNA Protein Name
NM_181885.3 NP_871001.1 relaxin-3 receptor 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24802387 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXFP4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (56 - 309)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

relaxin-3 receptor 2

  • G protein-coupled receptor 100

RXFP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RXFP4 Q8TDU9 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
RXFP4 Q8TDU9 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
RXFP4 Q8TDU9 RLN3 Homo sapiens Q8WXF3
Competition Binding
24802387
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Congenital Bile Acid Synthesis Defect

  • 3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency

  • Cba

  • Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency

  • Basd

  • Bile Acid Synthesis Defect, Congenital, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145278 RXFP3/4 agonist 2 99.75% Unkown
HY-P11246 A13:B7-24-GG Agonist / Unkown
HY-RS12360 RXFP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19739 Rxfp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26235 Rxfp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RXFP4 MGD MGI:2182926
Macaca mulatta RXFP4 VGNC VGNC:100126
Rattus norvegicus RXFP4 RGD RGD:2322332
Bos taurus RXFP4 VGNC VGNC:55676
Others RXFP4 NCBI