Prdx6 - peroxiredoxin 6 Gene

Also Known as GPx; Aop2; CP-3; Ltw4; Ltw-4; NSGPx; ORF06; Prdx5; Brp-12; Lvtw-4; aiPLA2; LPCAT-5; 1-cysPrx; 1-Cys Prx; 9430088D19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11758

Summary

This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has Glutathione Peroxidase and Phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane Phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]

Prdx6 Products (2)

mRNA Protein Name
NM_001303408.1 NP_001290337.1 peroxiredoxin-6 isoform 2
NM_007453.4 NP_031479.1 peroxiredoxin-6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
26830860 MGI
enables peroxidase activity IMP
IMP: Inferred from mutant phenotype
12732627 MGI
enables phospholipase A2 activity IMP
IMP: Inferred from mutant phenotype
26830860 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23401562 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within bleb assembly IMP
IMP: Inferred from mutant phenotype
17135244 MGI
acts upstream of or within response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
12732627 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
12732627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxiredoxin-6

  • 1-Cys peroxiredoxin

  • LPC acyltransferase 5

  • acidic calcium-independent phospholipase A2

  • anti-oxidant protein 2, related sequence 3

  • antioxidant protein 2

  • glutathione-dependent peroxiredoxin

  • lyso-PC acyltransferase 5

  • lysophosphatidylcholine acyltransfe

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-115062 MJ33 lithium salt Inhibitor 99.0% Unkown
HY-129944A MJ33-OH lithium Inhibitor ≥90.0% Unkown
HY-RS11078 PRDX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129944 MJ33-OH Inhibitor / Unkown
HY-136271 MJ33 Inhibitor / Unkown
HY-RS11079 PRDX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17470 Prdx6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17919 Prdx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23928 Prdx6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdx6 NCBI NCBI:9588