Phb2 - prohibitin 2 Gene

Also Known as BAP; REA; Bap37; Bcap37

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12034

Summary

Enables sphingolipid binding activity. Involved in several processes, including CD40 signaling pathway; regulation of gene expression; and regulation of phosphate metabolic process. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular Estrogen receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of inner mitochondrial membrane protein complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]

Phb2 Products (1)

mRNA Protein Name
NM_007531.2 NP_031557.2 prohibitin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12878603 MGI
enables sphingolipid binding IDA
IDA: Inferred from direct assay
20959514 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell activation IDA
IDA: Inferred from direct assay
23241883 MGI
acts upstream of estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17065319 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
17065319 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: Inferred from mutant phenotype
17065319 MGI
acts upstream of mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17065319 MGI
involved in mitophagy IDA
IDA: Inferred from direct assay
28017329 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15140878 MGI
acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway IGI
IGI: Inferred from genetic interaction
17785450 MGI
acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17065319 MGI
acts upstream of or within negative regulation of mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17065319 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
23241883 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
23241883 MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
17065319 MGI
involved in regulation of cardiolipin metabolic process IMP
IMP: Inferred from mutant phenotype
24856930 MGI
involved in regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
20959514 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
22417827 MGI
part of inner mitochondrial membrane protein complex IDA
IDA: Inferred from direct assay
24856930 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
11302691 MGI
part of mitochondrial prohibitin complex IPI
IPI: Inferred from physical interaction
20959514 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14651853 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15140878 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prohibitin-2

  • B-cell receptor-associated protein 37

  • B-cell receptor-associated protein BAP37

  • repressor of estrogen receptor activity

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114989 Fluorizoline Inducer 99.77% Unkown
HY-152093 YL-939 Inhibitor 99.03% Unkown
HY-117113 JI051 Inhibitor 98.0% Unkown
HY-124484 JI130 Inhibitor 99.41% Unkown
HY-162904 BPU17 98.16% Unkown
HY-RS16807 Phb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179574 AURKA-IN-4 Inhibitor 99.88% Unkown
HY-RS10408 PHB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23247 Phb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phb2 NCBI NCBI:11331