Bub1 - BUB1, mitotic checkpoint serine/threonine kinase Gene

Also Known as Bub1a; D2Xrf87

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12235

Summary

Predicted to enable protein kinase activity. Acts upstream of or within chromosome segregation and positive regulation of intrinsic apoptotic signaling pathway. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Bub1 Products (2)

mRNA Protein Name
NM_001113179.1 NP_001106650.1 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1
NM_009772.2 NP_033902.2 mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
17938250 MGI
acts upstream of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17938250 MGI
acts upstream of or within mitotic spindle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17938250 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17938250 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
12355205 MGI
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
18084284 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
15226446 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitotic checkpoint serine/threonine-protein kinase BUB1

  • budding uninhibited by benzimidazoles 1 homolog

  • mBUB1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103020 BAY-1816032 Inhibitor 99.73% Unkown
HY-104001 BAY-524 Inhibitor 98.36% Unkown
HY-102081 2OH-BNPP1 Inhibitor 99.65% Unkown
HY-104000 BAY-320 Inhibitor 99.74% Unkown
HY-172089 TG101209 analog 1 Inducer 98.27% Unkown
HY-161865 Antitumor agent-180 Inducer 99.46% Unkown
HY-RS01681 BUB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01682 BUB1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-RS17020 Bub1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19413 Bub1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23463 Bub1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25905 Bub1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bub1 NCBI NCBI:699