Cdk11b - cyclin-dependent kinase 11B Gene

Also Known as p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12537

About Cdk11b

Chromosome 4: 155,709,311-155,734,395 forward strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 203 orthologues, 25 paralogues and is associated with 8 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 24.), large intestine adult (RPKM 15.5) and 28 other tissues.

Summary

Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]

Cdk11b Products (5)

mRNA Protein Name
NM_001347308.1 NP_001334237.1 cyclin-dependent kinase 11B isoform 2
NM_001355568.1 NP_001342497.1 cyclin-dependent kinase 11B isoform 2
NM_001355569.1 NP_001342498.1 cyclin-dependent kinase 11B isoform 4
NM_007661.4 NP_031687.2 cyclin-dependent kinase 11B isoform 1
NM_001355567.1 NP_001342496.1 cyclin-dependent kinase 11B isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
15060143 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15060143 MGI
acts upstream of or within regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
15060143 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15060143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk11b Protein Structure

STKc_CDC2L1

STKc_CDC2L1: cd07843 (420 - 711)

  • 0
  • 200
  • 400
  • 600
  • 784 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 11B

  • PITSLRE proteins

  • PITSLRE serine/threonine-protein kinase CDC2L1

  • cell division cycle 2 homolog-like 1

  • cell division cycle 2 homolog-like 2

  • cell division cycle 2-like 1

  • cell division cycle 2-like 2

  • cell division cycle 2-like protein kinase 1

  • cell division protein kinase 11

  • cyclin-dependent kinase 11

  • galactosyltransferase-associated protein kinase p58/GTA

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12467 OTS964 hydrochloride 99.74% Unkown
HY-155874 ZNL-05-044 Inhibitor 99.11% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-19718 OTS964 / Unkown
HY-RS02353 CDK11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02354 Cdk11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02355 Cdk11b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk11b NCBI NCBI:984