CDK11B - cyclin dependent kinase 11B Gene

Also Known as p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 984

About CDK11B

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,635,225-1,659,004 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 20.1), bone marrow (RPKM 18.4) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CDK11B Products (30)

mRNA Protein Name
XM_011542494.4 XP_011540796.1 cyclin-dependent kinase 11B isoform X7
NM_033493.1
XM_011542492.3 XP_011540794.1 cyclin-dependent kinase 11B isoform X1
NM_033488.1
XM_047435362.1 XP_047291318.1 cyclin-dependent kinase 11B isoform X12
XM_047435361.1 XP_047291317.1 cyclin-dependent kinase 11B isoform X11
XM_017002925.3 XP_016858414.1 cyclin-dependent kinase 11B isoform X4
NM_033490.3 NP_277025.1 cyclin-dependent kinase 11B isoform 6
NM_033492.1
XM_047435367.1 XP_047291323.1 cyclin-dependent kinase 11B isoform X14
NM_001291345.2 NP_001278274.1 cyclin-dependent kinase 11B isoform 10
XM_047435355.1 XP_047291311.1 cyclin-dependent kinase 11B isoform X9
NM_033486.3 NP_277021.2 cyclin-dependent kinase 11B isoform 2
XM_011542491.3 XP_011540793.1 cyclin-dependent kinase 11B isoform X1
XM_047435371.1 XP_047291327.1 cyclin-dependent kinase 11B isoform X17
XM_011542490.4 XP_011540792.1 cyclin-dependent kinase 11B isoform X1
NM_033489.3 NP_277024.2 cyclin-dependent kinase 11B isoform 5
XM_047435330.1 XP_047291286.1 cyclin-dependent kinase 11B isoform X2
XM_047435368.1 XP_047291324.1 cyclin-dependent kinase 11B isoform X15
XM_006711065.5 XP_006711128.1 cyclin-dependent kinase 11B isoform X5
XM_017002928.3 XP_016858417.1 cyclin-dependent kinase 11B isoform X8
XM_047435360.1 XP_047291316.1 cyclin-dependent kinase 11B isoform X10
NM_033487.3 NP_277022.1 cyclin-dependent kinase 11B isoform 3
XM_047435363.1 XP_047291319.1 cyclin-dependent kinase 11B isoform X13
XM_017002926.3 XP_016858415.1 cyclin-dependent kinase 11B isoform X6
NM_001787.3 NP_001778.2 cyclin-dependent kinase 11B isoform 1
XM_011542493.4 XP_011540795.1 cyclin-dependent kinase 11B isoform X3
XM_024451190.2 XP_024306958.1 cyclin-dependent kinase 11B isoform X18
XM_047435369.1 XP_047291325.1 cyclin-dependent kinase 11B isoform X16
XM_047435328.1 XP_047291284.1 cyclin-dependent kinase 11B isoform X2

CDK11B Protein Structure

Pkinase

Pkinase: Protein kinase domain (428 - 713)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 11B

  • CDC-related protein kinase p58

  • PITSLRE serine/threonine-protein kinase CDC2L1

  • cell division cycle 2-like 1 (PITSLRE proteins)

  • cell division protein kinase 11B

  • galactosyltransferase-associated protein kinase p58/GTA

  • p58 CLK-1

Related Diseases

Diseases Alias
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Childhood Endodermal Sinus Tumor

  • Childhood Endodermal Sinus Neoplasm

  • Childhood Endodermal Sinus Tumour

  • Paediatric Yolk Sac Tumour

  • Pediatric Yolk Sac Tumor

  • Childhood Yolk Sac Tumor
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12467 OTS964 hydrochloride 99.74% Unkown
HY-155874 ZNL-05-044 Inhibitor 99.11% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-19718 OTS964 / Unkown
HY-RS02353 CDK11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02354 Cdk11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02355 Cdk11b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CDK11B MGD MGI:88353
Rattus norvegicus CDK11B RGD RGD:628604