ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

Also Known as ADH-2; HEL-S-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 127

About ADH4

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,123,658-99,144,297 (from NCBI)

This gene has 11 transcripts (splice variants), 346 orthologues and 17 paralogues. Restricted expression toward liver (RPKM 940.8).

Summary

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

ADH4 Products (3)

mRNA	Protein	Name
NM_000670.5	NP_000661.2	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2
NM_001306171.2	NP_001293100.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1
NM_001306172.2	NP_001293101.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables NAD binding	IDA IDA: Inferred from direct assay	10407146	GOA
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	3466164	GOA
enables all-trans retinal binding	IDA IDA: Inferred from direct assay	15369820	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	10514444	GOA
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	3466164	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables retinol binding	IDA IDA: Inferred from direct assay	10407146	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	10407146	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in alcohol metabolic process	IDA IDA: Inferred from direct assay	3466164	GOA
involved in cellular aldehyde metabolic process	IDA IDA: Inferred from direct assay	3466164	GOA
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	16081420	GOA
involved in retinoid metabolic process	IDA IDA: Inferred from direct assay	15369820	GOA
involved in retinol metabolic process	IDA IDA: Inferred from direct assay	16787387	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH4 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
all-trans-retinol dehydrogenase [NAD(+)] ADH4	alcohol dehydrogenase class II pi chain

ADH4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADH4	P08319	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ADH4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86764	ADH4 Antibody(YA6457)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome
Cluster Headache	Headache, Cluster
Hypocalciuric Hypercalcemia, Familial, Type Ii	HHC2 Familial Hypocalciuric Hypercalcemia 2 Fbh2 Familial Hypocalciuric Hypercalcemia Type 2 Hypocalciuric Hypercalcemia, Type Ii Fhh Type 2 Familial Benign Hypercalcemia, Type Ii Hypercalcemia, Familial Benign, Type Ii Hypocalciuric Hypercalcemia Type Ii Familial Benign Hypercalcemia, Type 2 Hypercalcemia, Familial Benign Type 2 Hypocalciuric Hypercalcemia, Familial, Type 2 Hypocalciuric Hypercalcemia, Familial 2 Familial Benign Hypercalcemia Type Ii Hypocalciuric Hypercalcemia-2
Hypocalciuric Hypercalcemia, Familial, Type I	HHC1 Familial Hypocalciuric Hypercalcemia 1 Fhh1 Familial Benign Hypercalcemia 1 Fbh1 Hypocalciuric Hypercalcemia, Type I Fhh Type 1 Hhc Fhh Hypercalcemia, Familial Benign Hypocalciuric Hypercalcemia Type I Familial Hypocalciuric Hypercalcemia Type 1 Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Hypocalciuric Hypercalcemia Type I Familial Benign Hypercalcemia Type 1 Hypercalcemia, Familial Benign Type 1 Hypocalciuric Hypercalcemia, Familial 1 Familial Benign Hypocalciuric Hypercalcemia 1 Fbhh1
Substance Dependence
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Headache	Headache Disorder
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Familial Isolated Hypoparathyroidism	Fih
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00369	ADH4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00374	ADH7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18599	Adh4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19572	Adh7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25084	Adh4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADH4	RGD	RGD:71028
Mus musculus	ADH4	MGD	MGI:1349472