Cobl - cordon-bleu WH2 repeat Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12808

Summary

Enables actin monomer binding activity. Involved in actin filament organization; collateral sprouting in absence of injury; and positive regulation of cell projection organization. Acts upstream of or within several processes, including chordate embryonic development; liver development; and notochord development. Located in several cellular components, including growth cone; ruffle; and terminal web. Colocalizes with actin filament. Is expressed in several structures, including central nervous system; chordamesoderm; embryo mesenchyme; gut; and nose. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Apr 2022]

Cobl Products (9)

mRNA	Protein	Name
NM_001282993.2	NP_001269922.1	protein cordon-bleu isoform 2
NM_001282994.2	NP_001269923.1	protein cordon-bleu isoform 3
NM_001401095.1	NP_001388024.1	protein cordon-bleu isoform 4
NM_001401096.1	NP_001388025.1	protein cordon-bleu isoform 5
NM_001401097.1	NP_001388026.1	protein cordon-bleu isoform 6
NM_001401098.1	NP_001388027.1	protein cordon-bleu isoform 7
NM_001401099.1	NP_001388028.1	protein cordon-bleu isoform 8
NM_001401100.1	NP_001388029.1	protein cordon-bleu isoform 9
NM_172496.4	NP_766084.3	protein cordon-bleu isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin monomer binding	IDA IDA: Inferred from direct assay	17956734	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17956734	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	29891944	MGI
involved in actin filament network formation	IDA IDA: Inferred from direct assay	17956734	MGI
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	17956734	MGI
involved in collateral sprouting in absence of injury	IMP IMP: Inferred from mutant phenotype	17956734	MGI
involved in digestive tract development	IEP IEP: Inferred from expression pattern	7586755	MGI
involved in embryonic axis specification	IEP IEP: Inferred from expression pattern	7586755	MGI
involved in floor plate development	IEP IEP: Inferred from expression pattern	7586755	MGI
involved in liver development	IEP IEP: Inferred from expression pattern	7586755	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	14512015	MGI
involved in notochord development	IEP IEP: Inferred from expression pattern	7586755	MGI
involved in positive regulation of dendrite development	IDA IDA: Inferred from direct assay	21725280	MGI
involved in positive regulation of ruffle assembly	IDA IDA: Inferred from direct assay	17956734	MGI
involved in somite specification	IEP IEP: Inferred from expression pattern	7586755	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	17956734	MGI
located in axon	IDA IDA: Inferred from direct assay	17956734	MGI
located in axonal growth cone	IDA IDA: Inferred from direct assay	17956734	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	21725280	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17956734	MGI
located in dendritic growth cone	IDA IDA: Inferred from direct assay	17956734	MGI
located in membrane	IDA IDA: Inferred from direct assay	21725280	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	17956734	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21725280	MGI
located in ruffle	IDA IDA: Inferred from direct assay	17956734	MGI
located in terminal web	IDA IDA: Inferred from direct assay	22114352	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein cordon-bleu

Cobl Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Cobl	Q5NBX1	Pacsin1	Rattus norvegicus	Q9Z0W5	Anti Tag CoIP	21725280
Cross	Cobl	Q5NBX1	Pacsin1	Rattus norvegicus	Q9Z0W5	Far-WB	21725280
Cross	Cobl	Q5NBX1	Pacsin1	Rattus norvegicus	Q9Z0W5	Pull Down	21725280
Cross	Cobl	Q5NBX1	Pacsin2	Rattus norvegicus	Q9QY17	Far-WB	21725280
Cross	Cobl	Q5NBX1	Pacsin2	Rattus norvegicus	Q9QY17	Pull Down	21725280
Cross	Cobl	Q5NBX1	Pacsin3	Rattus norvegicus	Q5I2Z0	Far-WB	21725280

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02947	COBL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cobl	NCBI	NCBI:23242