Pacsin2 - protein kinase C and casein kinase substrate in neurons 2 Gene

Also Known as SdpII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 124461

Summary

Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and phosphatidic acid binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; plasma membrane organization; and protein localization to endosome. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in several cellular components, including caveola; nuclear speck; and recycling endosome membrane. Predicted to be extrinsic component of membrane. Predicted to be active in endosome; glutamatergic synapse; and plasma membrane. Orthologous to human PACSIN2 (protein kinase C and Casein Kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]

Pacsin2 Products (1)

mRNA Protein Name
NM_130740.2 NP_570096.2 protein kinase C and casein kinase substrate in neurons 2 protein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15371016 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein kinase C and casein kinase substrate in neurons 2 protein

  • SdpIIsyndapin II

  • synaptic dynamin-associated protein II

  • syndapin-2

  • syndapin-II

Pacsin2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Pacsin2 Q9QY17 Cobl Mus musculus Q5NBX1
Pull Down
21725280
Cross
Pacsin2 Q9QY17 PDE6G Homo sapiens P18545
Y2H
16357825
Cross
Pacsin2 Q9QY17 Ehd4 Mus musculus Q9EQP2
Pull Down
15371016
Intra
Pacsin2 Q9QY17 Ehd1 Rattus norvegicus Q641Z6
CoIP
15371016
Cross
Pacsin2 Q9QY17 NCKIPSD Homo sapiens Q9NZQ3
Affinity Chrom
16999739
Cross
Pacsin2 Q9QY17 NCKIPSD Homo sapiens Q9NZQ3
Pull Down
16999739
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09958 PACSIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22015 Pacsin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pacsin2 NCBI NCBI:11252