LYPD6 - LY6/PLAUR domain containing 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 130574

About LYPD6

Cytogenetic location: 2q23.2 Genomic coordinates (GRCh38): 2:149,329,985-149,486,378 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 1 paralogue. Biased expression in gall bladder (RPKM 7.3), placenta (RPKM 6.8) and 12 other tissues.

Summary

Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]

LYPD6 Products (2)

mRNA Protein Name
NM_001195685.2 NP_001182614.1 ly6/PLAUR domain-containing protein 6 precursor
NM_194317.5 NP_919298.1 ly6/PLAUR domain-containing protein 6 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables acetylcholine receptor inhibitor activity IDA
IDA: Inferred from direct assay
27344019 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27344019 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ly6/PLAUR domain-containing protein 6

LYPD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LYPD6 Q86Y78 SS18L2 Homo sapiens Q9UHA2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mal De Meleda

  • Meleda Disease

  • Keratosis Palmoplantaris Transgrediens Of Siemens

  • MDM

  • Transgrediens Palmoplantar Keratoderma Of Siemens

  • Acroerythrokeratoderma

  • Keratosis Palmoplantaris Transgradiens Of Siemens
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07918 LYPD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07919 LYPD6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LYPD6 VGNC VGNC:80272
Bos taurus LYPD6 VGNC VGNC:31103
Rattus norvegicus LYPD6 RGD RGD:1587119
Canis familiaris LYPD6 VGNC VGNC:42888
Mus musculus LYPD6 MGD MGI:2443848
Macaca mulatta LYPD6 VGNC VGNC:99377
Others LYPD6 NCBI