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MTERF4 - mitochondrial transcription termination factor 4 Gene

Also Known as MTERFD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 130916

About MTERF4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,042,586-241,102,287 (from NCBI)

This gene has 22 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in ovary (RPKM 7.9), thyroid (RPKM 7.8) and 25 other tissues.

Summary

Enables rRNA binding activity. Predicted to be involved in rRNA processing and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

MTERF4 Products (3)

mRNA	Protein	Name
NM_001330179.2	NP_001317108.1	transcription termination factor 4, mitochondrial isoform 2
NM_001330180.2	NP_001317109.1	transcription termination factor 4, mitochondrial isoform 3
NM_182501.4	NP_872307.2	transcription termination factor 4, mitochondrial isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21531335	GOA
enables rRNA binding	IDA IDA: Inferred from direct assay	21531335	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mitochondrial large ribosomal subunit	IDA IDA: Inferred from direct assay	21531335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTERF4 Protein Structure

mTERF

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
transcription termination factor 4, mitochondrial	MTERF domain-containing protein 2

MTERF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MTERF4	Q7Z6M4	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	MTERF4	Q7Z6M4	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	MTERF4	Q7Z6M4	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	MTERF4	Q7Z6M4	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	MTERF4	Q7Z6M4	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	MTERF4	Q7Z6M4	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	MTERF4	Q7Z6M4	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	MTERF4	Q7Z6M4	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	Pull Down	22949673
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	X-Ray Diffraction	23022348
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	GMS	22949673
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	X-Ray Diffraction	22949673
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	GMS	23022348
Intra	MTERF4	Q7Z6M4	NSUN4	Homo sapiens	Q96CB9-1	ITC	23022348
Intra	MTERF4	Q7Z6M4	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	MTERF4	Q7Z6M4	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	MTERF4	Q7Z6M4	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	MTERF4	Q7Z6M4	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Raynaud-Claes Syndrome	Mrx49 MRXSRC Mental Retardation, X-Linked 49 Mrx15 Clcn4-Related X-Linked Intellectual Disability Syndrome Mental Retardation, X-Linked 15 X-Linked Mental Retardation 15 X-Linked Mental Retardation 49 Mental Retardation, X-Linked-49
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08764	MTERF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTERF4	VGNC	VGNC:63646
Bos taurus	MTERF4	VGNC	VGNC:55065
Mus musculus	MTERF4	MGD	MGI:1918355
Rattus norvegicus	MTERF4	RGD	RGD:1562440
Macaca mulatta	MTERF4	VGNC	VGNC:74849
Others	MTERF4	NCBI