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Drd1 - dopamine receptor D1 Gene

Also Known as Drd-1; Drd1a; Gpcr15; C030036C15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13488

About Drd1

Chromosome 13: 54,205,202-54,209,724 reverse strand.GRCm39:CM001006.3

This gene has 3 transcripts (splice variants), 262 orthologues, 32 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.8) and 5 other tissues.

Summary

Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in modification of postsynaptic structure and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and glutamatergic synapse. Is integral component of presynaptic membrane. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (Dopamine Receptor D1). [provided by Alliance of Genome Resources, Apr 2022]

Drd1 Products (2)

mRNA	Protein	Name
NM_010076.3	NP_034206.1	D(1A) dopamine receptor
NM_001291801.1	NP_001278730.1	D(1A) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	14712229	MGI
enables dopamine neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	18671743	MGI
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA IDA: Inferred from direct assay	7566118	MGI
enables dopamine neurotransmitter receptor activity, coupled via Gs	IMP IMP: Inferred from mutant phenotype	7809078	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9016340	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within D-glucose import	IMP IMP: Inferred from mutant phenotype	11251190	MGI
acts upstream of or within G protein-coupled dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	11089973	MGI
acts upstream of or within G protein-coupled dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16908842	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14712229	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11404425	MGI
acts upstream of or within activation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	12488442	MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	8738226	MGI
involved in adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	23842570	MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12223546	MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9016340	MGI
acts upstream of or within adult walking behavior	IGI IGI: Inferred from genetic interaction	9354330	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	7954836	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	9692749	MGI
acts upstream of or within astrocyte development	IMP IMP: Inferred from mutant phenotype	17360497	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	11172752	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	16014726	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	15932618	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	17360497	MGI
acts upstream of or within dopamine transport	IMP IMP: Inferred from mutant phenotype	11404425	MGI
acts upstream of or within feeding behavior	IGI IGI: Inferred from genetic interaction	15272078	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	9749770	MGI
acts upstream of or within habituation	IMP IMP: Inferred from mutant phenotype	11985822	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	17360497	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	15684065	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	10884517	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	8001143	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	14981263	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	9427321	MGI
acts upstream of or within maternal behavior	IMP IMP: Inferred from mutant phenotype	7809078	MGI
acts upstream of or within mating behavior	IDA IDA: Inferred from direct assay	9829800	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	10585522	MGI
involved in modification of postsynaptic structure	EXP EXP: Inferred from Experiment	25258080	MGI
involved in modification of postsynaptic structure	IDA IDA: Inferred from direct assay	25258080	MGI
acts upstream of or within muscle contraction	IMP IMP: Inferred from mutant phenotype	17360497	MGI
acts upstream of neuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	16908842	MGI
acts upstream of or within operant conditioning	IMP IMP: Inferred from mutant phenotype	12603275	MGI
acts upstream of or within peristalsis	IGI IGI: Inferred from genetic interaction	15272078	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	15016423	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17194762	MGI
acts upstream of or within positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	8795639	MGI
NOT acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	12417685	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	22586226	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	22586226	MGI
acts upstream of or within protein import into nucleus	EXP EXP: Inferred from Experiment	18496528	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	18496528	MGI
acts upstream of or within regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11438590	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18496528	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	11823893	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	9261820	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	9387887	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7549459	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	11251190	MGI
acts upstream of or within sensitization	IGI IGI: Inferred from genetic interaction	11823893	MGI
NOT acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	17324452	MGI
acts upstream of or within striatum development	IMP IMP: Inferred from mutant phenotype	17360497	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	16908842	MGI
acts upstream of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	8795639	MGI
acts upstream of or within temperature homeostasis	IMP IMP: Inferred from mutant phenotype	18486343	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	12867509	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	9692749	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	27035941	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	25865831	MGI
located in endomembrane system	IDA IDA: Inferred from direct assay	24550737	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24550737	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	25258080	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25258080	MGI
located in membrane	IDA IDA: Inferred from direct assay	7809078	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9387887	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	24550737	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	27035941	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	27035941	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd1 Protein Structure

7tm_GPCRs

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
D(1A) dopamine receptor	D1 receptor D1A dopamine receptor G protein-coupled receptor DRD1 dopamine D1 receptor dopamine receptor D1A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03622	Ddr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03994	DRD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03995	Drd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03996	Drd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd1	NCBI	NCBI:1812