CSF2RA - colony stimulating factor 2 receptor subunit alpha Gene

Homo sapiens

Also known as GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; alphaGMR; GMR-alpha; GMCSFR-alpha; GM-CSF-R-alpha

Gene ID: 1438 | Gene type: protein coding

About CSF2RA

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,268,814-1,325,218 (from NCBI)

This gene has 18 transcripts (splice variants), 112 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 20.8), appendix (RPKM 7.7) and 14 other tissues.

Summary

The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and Others being soluble. [provided by RefSeq, Jul 2008]

CSF2RA Products(25)

mRNA	Protein	Name
NM_001161529.2	NP_001155001.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor
NM_001161530.2	NP_001155002.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor
NM_001161531.2	NP_001155003.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor
NM_001161532.2	NP_001155004.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h
NM_001379153.1	NP_001366082.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor
NM_001379154.1	NP_001366083.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor
NM_001379155.1	NP_001366084.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor
NM_001379156.1	NP_001366085.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor
NM_001379158.1	NP_001366087.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor
NM_001379159.1	NP_001366088.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform i precursor
NM_001379160.1	NP_001366089.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform j precursor
NM_001379161.1	NP_001366090.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform k precursor
NM_001379162.1	NP_001366091.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor
NM_001379163.1	NP_001366092.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform l precursor
NM_001379164.1	NP_001366093.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor
NM_001379165.1	NP_001366094.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform m precursor
NM_001379166.1	NP_001366095.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform n precursor
NM_001379167.1	NP_001366096.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor
NM_001379168.1	NP_001366097.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor
NM_001379169.1	NP_001366098.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor
NM_006140.6	NP_006131.2	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor
NM_172245.4	NP_758448.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor
NM_172246.4	NP_758449.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform b precursor
NM_172247.3	NP_758450.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor
NM_172249.4	NP_758452.1	granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform e precursor

CSF2RA Protein Structure

IL6Ra-bind

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

granulocyte-macrophage colony-stimulating factor receptor subunit alpha

CD116 antigen

Recombinant CSF2RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7783	GM-CSF R alpha Protein, Human (HEK293, His)	P15509 (E23-G320)	≥95%
HY-P73083	GM-CSF R alpha Protein, Human (HEK293, Fc)	P15509 (E23-G320)	≥95%
HY-P73084	GM-CSF R alpha Protein, Human (320a.a, HEK293, His)	P15509 (M1-G320)	≥95%
HY-P78110	GM-CSF R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	P15509 (E23-G320)	≥95%

Related Diseases

Diseases

Alias

Surfactant Metabolism Dysfunction, Pulmonary, 4

SMDP4	Pap Due To Csf2ra Deficiency
Csf2ra Deficiency	Pulmonary Alveolar Proteinosis, Congenital, 4
Pulmonary Surfactant Metabolism Dysfunction 4	Congenital Pulmonary Alveolar Proteinosis 4
Pap	Surfactant Metabolism Dysfunction, Pulmonary, Type 4

Hereditary Pulmonary Alveolar Proteinosis

Congenital Pap	Congenital Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis, Congenital

Pulmonary Alveolar Proteinosis

Amoxicillin Allergy

Brain Stem Astrocytic Neoplasm

Brainstem Astrocytoma

Astrocytoma Of Brain Stem

Mucocele Of Salivary Gland

Ranula	Salivary Cyst
Salivary Gland Mucocele	Mucous Retention Cyst Of Salivary Gland
Retention Cyst Of Salivary Gland	Sialocele
Cyst Of Salivary Gland Or Duct	Extravasation Cyst Of Salivary Gland

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03232	CSF2RA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CSF2RA	MGD	MGI:1339754
Bos taurus	CSF2RA	VGNC	VGNC:55042
Canis familiaris	CSF2RA	VGNC	VGNC:39655
Rattus norvegicus	CSF2RA	RGD	RGD:1594330
Macaca fascicularis	CSF2RA	NCBI

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