CPNE8 - copine 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 144402

About CPNE8

This gene has 9 transcripts (splice variants), 203 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 2.0), placenta (RPKM 2.0) and 24 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an Integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]

CPNE8 Products (1)

mRNA Protein Name
NM_153634.3 NP_705898.1 copine-8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE8 Protein Structure

C2

C2: C2 domain (30 - 116)

C2

C2: C2 domain (164 - 248)

Copine

Copine: Copine (328 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
Protein Preferred Names Protein Names

copine-8

  • copine VIII

CPNE8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CPNE8 Q86YQ8 NECAB1 Homo sapiens Q8N987
Y2H Prey Pooling
32296183
Intra
CPNE8 Q86YQ8 NECAB1 Homo sapiens Q8N987
Validated Y2H
32296183
Intra
CPNE8 Q86YQ8 NECAB1 Homo sapiens Q8N987
Y2H Array
32296183
Intra
CPNE8 Q86YQ8 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
CPNE8 Q86YQ8 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03110 CPNE8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPNE8 VGNC VGNC:39567
Felis catus CPNE8 VGNC VGNC:61135
Rattus norvegicus CPNE8 RGD RGD:1307939
Bos taurus CPNE8 VGNC VGNC:27664
Macaca mulatta CPNE8 VGNC VGNC:104704
Mus musculus CPNE8 MGD MGI:1914121
Others CPNE8 NCBI