NECAB1 - N-terminal EF-hand calcium binding protein 1 Gene

Also Known as EFCBP1; STIP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64168

About NECAB1

This gene has 6 transcripts (splice variants), 188 orthologues and 2 paralogues. Biased expression in brain (RPKM 31.1), testis (RPKM 8.9) and 12 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in regulation of amyloid precursor protein biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NECAB1 Products (1)

mRNA Protein Name
NM_022351.5 NP_071746.1 N-terminal EF-hand calcium-binding protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECAB1 Protein Structure

EF-hand_5

EF-hand_5: EF hand (33 - 55)

ABM

ABM: Antibiotic biosynthesis monooxygenase (254 - 325)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

N-terminal EF-hand calcium-binding protein 1

  • EF-hand calcium-binding protein 1

NECAB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NECAB1 Q8N987 PAX4 Homo sapiens Q3KNR5
Y2H Array
32296183
Intra
NECAB1 Q8N987 PAX4 Homo sapiens Q3KNR5
Y2H Prey Pooling
32296183
Intra
NECAB1 Q8N987 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra
NECAB1 Q8N987 SNX11 Homo sapiens Q9Y5W9
Y2H Array
32296183
Intra
NECAB1 Q8N987 SNX11 Homo sapiens Q9Y5W9
Y2H Prey Pooling
32296183
Intra
NECAB1 Q8N987 SNX11 Homo sapiens Q9Y5W9
Validated Y2H
32296183
Intra
NECAB1 Q8N987 NECAB1 Homo sapiens Q8N987
Complementation
32296183
Intra
NECAB1 Q8N987 NECAB1 Homo sapiens Q8N987
Y2H Prey Pooling
32296183
Intra
NECAB1 Q8N987 NECAB1 Homo sapiens Q8N987
Validated Y2H
32296183
Intra
NECAB1 Q8N987 NECAB1 Homo sapiens Q8N987
MAPPIT
32296183
Intra
NECAB1 Q8N987 NECAB1 Homo sapiens Q8N987
Y2H Array
32296183
Intra
NECAB1 Q8N987 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
NECAB1 Q8N987 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
NECAB1 Q8N987 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
NECAB1 Q8N987 CPNE7 Homo sapiens Q9UBL6-2
Validated Y2H
32296183
Intra
NECAB1 Q8N987 CPNE4 Homo sapiens Q96A23-2
Validated Y2H
32296183
Intra
NECAB1 Q8N987 CPNE4 Homo sapiens Q96A23-2
Y2H Prey Pooling
32296183
Intra
NECAB1 Q8N987 CPNE4 Homo sapiens Q96A23-2
Y2H Array
32296183
Intra
NECAB1 Q8N987 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
NECAB1 Q8N987 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Motor Neuron Disease

  • Anterior Horn Cell Disease

  • Motor Neuron Diseases

  • Mnd - [Motor Neurone Disease]

  • Lou Gehrig Disease

  • Creeping Palsy

  • Creeping Paralysis

  • Bulbar Motor Neuron Disease

  • Bulbar Syndrome

  • Anterior Horn Cell Disorder

  • Hereditary Motor Neuron Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09170 NECAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NECAB1 VGNC VGNC:63762
Macaca mulatta NECAB1 VGNC VGNC:75223
Canis familiaris NECAB1 VGNC VGNC:43714
Mus musculus NECAB1 MGD MGI:1916602
Rattus norvegicus NECAB1 RGD RGD:708548
Others NECAB1 NCBI