Gpr50 - G-protein-coupled receptor 50 Gene

Also Known as H9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14765

Summary

This gene encodes a multipass membrane protein that is thought to act as a G protein-coupled receptor. Activity of this protein may be important in neurotransmitter and glucocorticoid signalling. Mutation of this gene causes a decreased ability to maintain a constant body temperature, resulting in torpor, as well as an increased metabolic rate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Gpr50 Products (2)

mRNA Protein Name
NM_001308501.1 NP_001295430.1 melatonin-related receptor isoform 2
NM_010340.2 NP_034470.1 melatonin-related receptor isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21858214 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melatonin-related receptor

Gpr50 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Confocal
21858214
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Anti Tag CoIP
21858214
Intra
Gpr50 O88495 Kat5 Mus musculus Q8CHK4
Y2H
21858214
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05717 GPR50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20942 Gpr50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27459 Gpr50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr50 NCBI NCBI:9248