Kat5 - K(lysine) acetyltransferase 5 Gene

Also Known as PLIP; CPLA2; Tip55; Tip60; Htatip; Htatip1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81601

Summary

Enables peptide-lysine-N-acetyltransferase activity and transcription coactivator activity. Involved in peptidyl-lysine acetylation and positive regulation of Autophagy. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]

Kat5 Products (7)

mRNA Protein Name
NM_001199247.1 NP_001186176.1 histone acetyltransferase KAT5 isoform 2
NM_001199248.1 NP_001186177.1 histone acetyltransferase KAT5 isoform 3
NM_001199249.1 NP_001186178.1 histone acetyltransferase KAT5 isoform 4
NM_001362370.1 NP_001349299.1 histone acetyltransferase KAT5 isoform 5
NM_001362371.1 NP_001349300.1 histone acetyltransferase KAT5 isoform 5
NM_001362372.1 NP_001349301.1 histone acetyltransferase KAT5 isoform 6
NM_178637.2 NP_848752.1 histone acetyltransferase KAT5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
30297459 MGI
enables histone acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
32542325 MGI
enables peptide-lysine-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
22539723 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12464179 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12464179 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
30297459 MGI
involved in apoptotic process IDA
IDA: Inferred from direct assay
30655546 MGI
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
30655546 MGI
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
30297459 MGI
involved in neural tube development IDA
IDA: Inferred from direct assay
30655546 MGI
involved in neurogenesis IDA
IDA: Inferred from direct assay
30655546 MGI
involved in peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
22539723 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
22539723 MGI
involved in positive regulation of circadian rhythm IDA
IDA: Inferred from direct assay
31294688 MGI
involved in positive regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
24835996 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15944124 MGI
involved in protein acetylation IMP
IMP: Inferred from mutant phenotype
30655546 MGI
involved in regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
32542325 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12464179 MGI
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
28694333 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
28694333 MGI
Cellular Component GO Annotation Evidence References Source
part of NuA4 histone acetyltransferase complex IDA
IDA: Inferred from direct assay
32542325 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12464179 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone acetyltransferase KAT5

  • 60 kDa Tat-interactive protein

  • HIV-1 tat interactive protein 1, 60 kDa homolog

  • HIV-1 tat interactive protein 1, homolog

  • Tat-interactive protein-60

  • histone acetyltransferase HTATIP

  • lysine acetyltransferase 5

  • protein 2-hydroxyisobutyryltransferase KAT

Kat5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kat5 Q8CHK4 Atxn1 Mus musculus P54254
Anti Bait CoIP
17110330
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110127 NU9056 98.81% Unkown
HY-102058 WM-1119 Inhibitor 99.57% Unkown
HY-123604 TH1834 99.79% Unkown
HY-123604A TH1834 dihydrochloride 99.89% Unkown
HY-168428 CHI-KAT8i5 98.00% Unkown
HY-RS07080 KAT5 Human Pre-designed siRNA Set A / Unkown
HY-RS17408 Kat5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23862 Kat5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kat5 NCBI NCBI:10524