Cxcl1 - chemokine (C-X-C motif) ligand 1 Gene

Also Known as KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14825

Summary

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]

Cxcl1 Products (1)

mRNA Protein Name
NM_008176.3 NP_032202.1 growth-regulated alpha protein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
30294880 MGI
involved in positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
10725737 MGI
involved in positive regulation of neutrophil mediated killing of fungus IDA
IDA: Inferred from direct assay
10725737 MGI
involved in positive regulation of superoxide anion generation IDA
IDA: Inferred from direct assay
10725737 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10725737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth-regulated alpha protein

  • C-X-C motif chemokine 1

  • GRO1 oncogene

  • KC/GR)-alpha

  • KC/GRO-alpha

  • alpha-chemokine

  • platelet-derived growth factor-inducible protein KC

  • secretory protein N51

Recombinant Cxcl1 Proteins

Cat. No. Product Name Accession Purity
HY-P7186 GRO-alpha/CXCL1 Protein, Mouse (CHO) P12850 (A25-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7188 GRO-alpha/CXCL1 Protein, Mouse P12850 (A25-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72684 GRO-alpha/CXCL1 Protein, Mouse (HEK293, His) P12850 (R20-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700167AF Animal-Free GRO-alpha/CXCL1 Protein, Mouse P12850 (N29-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700559 GRO-alpha/CXCL1 Protein, Mouse (His) P12850 (N29-K96) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-12927 SX-517 Antagonist 99.90% Unkown
HY-163475 CXCL-CXCR1/2-IN-1 Inhibitor 99.64% Unkown
HY-176464 GSK2220691 Inhibitor 99.96% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-106463 Hexaprofen / Unkown
HY-114366 BC-1485 Inhibitor / Unkown
HY-120544 BAY-386 Antagonist / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-N2573 Corydalmine Inhibitor 99.74% Unkown
HY-N2573A Corydalmine hydrochloride Inhibitor / Unkown
HY-RS03383 CXCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174727 Human CXCR2 mRNA / Unkown
HY-RS16613 Cxcl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23048 Cxcl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99127 Anti-Mouse CD54 Antibody (YN1/1.7.4) Inhibitor 95.00% Unkown
HY-P99120 Anti-Mouse CD11a Antibody (FD441.8) Inhibitor 95.00% Unkown
HY-P992045 HZD37-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl1 NCBI NCBI:2919