Hells - helicase, lymphoid specific Gene

Also Known as LSH; Lysh; PASG; YFK8; E130115I21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15201

Summary

Enables chromatin binding activity. Involved in DNA methylation-dependent heterochromatin assembly; maintenance of DNA methylation; and pericentric heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including central nervous system; gut; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Apr 2022]

Hells Products (1)

mRNA	Protein	Name
NM_008234.3	NP_032260.2	lymphocyte-specific helicase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	15448183	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16395332	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	15647320	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	11325543	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	11711429	MGI
acts upstream of or within chromosomal DNA methylation maintenance following DNA replication	IMP IMP: Inferred from mutant phenotype	11711429	MGI
acts upstream of or within heterochromatin formation	IMP IMP: Inferred from mutant phenotype	15448183	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	11325543	MGI
involved in lymphocyte proliferation	IEP IEP: Inferred from expression pattern	10781083	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11325543	MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	15105378	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11325543	MGI
involved in pericentric heterochromatin formation	IMP IMP: Inferred from mutant phenotype	14612388	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	11325543	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	14612388	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11555636	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	14612388	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lymphocyte-specific helicase	proliferation-associated SNF2-like protein

Hells Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hells	Q60848	Cbx2	Mus musculus	P30658	Anti Bait CoIP	17726103
Intra	Hells	Q60848	Dnmt3b	Mus musculus	O88509	Anti Bait CoIP	16395332
Intra	Hells	Q60848	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	17726103
Intra	Hells	Q60848	Bmi1	Mus musculus	P25916	Anti Bait CoIP	17726103

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06115	HELLS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20035	Hells Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26538	Hells Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hells	NCBI	NCBI:3070