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Hif1a - hypoxia inducible factor 1, alpha subunit Gene

Also Known as MOP1; bHLHe78; HIF1alpha; HIF1-alpha; HIF-1-alpha

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15251

Summary

This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, Apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Hif1a Products (3)

mRNA	Protein	Name
NM_001313919.1	NP_001300848.1	hypoxia-inducible factor 1-alpha isoform 1
NM_001313920.1	NP_001300849.1	hypoxia-inducible factor 1-alpha isoform 3
NM_010431.2	NP_034561.2	hypoxia-inducible factor 1-alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15456877	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21856340	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	25587068	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15456877	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24030251	MGI
enables E-box binding	IMP IMP: Inferred from mutant phenotype	24011070	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25587068	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	9113979	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19071119	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8702901	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26245371	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9368100	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B-1 B cell homeostasis	IMP IMP: Inferred from mutant phenotype	11854513	MGI
acts upstream of TOR signaling	IMP IMP: Inferred from mutant phenotype	20808783	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	14659802	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	17181398	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	9436976	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	9606183	MGI
acts upstream of bone mineralization	IMP IMP: Inferred from mutant phenotype	17181398	MGI
acts upstream of or within camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	22627278	MGI
acts upstream of or within cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	9436976	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	11691837	MGI
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	16287860	MGI
acts upstream of or within cellular response to hypoxia	IGI IGI: Inferred from genetic interaction	24011070	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	12972594	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15073147	MGI
involved in collagen metabolic process	IMP IMP: Inferred from mutant phenotype	18037992	MGI
involved in connective tissue replacement involved in inflammatory response wound healing	IMP IMP: Inferred from mutant phenotype	18037992	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	20808783	MGI
acts upstream of or within dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17215402	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	17215402	MGI
involved in elastin metabolic process	IMP IMP: Inferred from mutant phenotype	18037992	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	16787915	MGI
acts upstream of or within embryonic placenta development	IGI IGI: Inferred from genetic interaction	16287860	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	16287860	MGI
acts upstream of or within epithelial cell differentiation involved in mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	12620994	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	18037992	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12620994	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	20808783	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15328538	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	14659802	MGI
acts upstream of or within hemoglobin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16787915	MGI
acts upstream of or within hypoxia-inducible factor-1alpha signaling pathway	IDA IDA: Inferred from direct assay	8470821	MGI
acts upstream of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	20440072	MGI
acts upstream of or within intestinal epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	20808783	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16787915	MGI
acts upstream of or within intracellular oxygen homeostasis	IMP IMP: Inferred from mutant phenotype	9436976	MGI
acts upstream of or within iris morphogenesis	IGI IGI: Inferred from genetic interaction	22627278	MGI
acts upstream of or within lactate metabolic process	IMP IMP: Inferred from mutant phenotype	15328538	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	12620994	MGI
acts upstream of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10328919	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	15328538	MGI
acts upstream of or within negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20808783	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17181398	MGI
acts upstream of or within negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	17181398	MGI
acts upstream of or within negative regulation of growth	IMP IMP: Inferred from mutant phenotype	11691837	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10328919	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12972594	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	22081627	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	15456877	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	14659802	MGI
acts upstream of or within neural fold elevation formation	IMP IMP: Inferred from mutant phenotype	10328919	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	17215402	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12972594	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	9436976	MGI
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	18037992	MGI
acts upstream of or within positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16787915	MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	20440072	MGI
acts upstream of or within positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	19273585	MGI
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	25587068	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	17215402	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8702901	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24011070	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9113979	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284606	MGI
acts upstream of or within positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11691837	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15456877	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	15328538	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17437992	MGI
acts upstream of or within regulation of glycolytic process	IGI IGI: Inferred from genetic interaction	17437992	MGI
acts upstream of or within regulation of thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	15456877	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12832481	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	8702901	MGI
acts upstream of or within response to hypoxia	IGI IGI: Inferred from genetic interaction	17437992	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	9606183	MGI
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	25587068	MGI
acts upstream of or within response to muscle activity	IMP IMP: Inferred from mutant phenotype	15328538	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21212189	MGI
acts upstream of or within vasculature development	IGI IGI: Inferred from genetic interaction	18653562	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	12972594	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in euchromatin	IDA IDA: Inferred from direct assay	25587068	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	11818497	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	21546903	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11691837	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hypoxia-inducible factor 1-alpha	ARNT-interacting protein

Hif1a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Hif1a	Q61221	Foxa2	Mus musculus	P35583	Pull Down	20609350
Intra	Hif1a	Q61221	Foxa2	Mus musculus	P35583	Anti Bait CoIP	20609350
Intra	Hif1a	Q61221	Rorc	Mus musculus	P51450-2	Anti Bait CoIP	21871655
Intra	Hif1a	Q61221	Rbfox3	Mus musculus	Q8BIF2	Anti Bait CoIP	21871655
Intra	Hif1a	Q61221	Arnt	Mus musculus	P53762	Anti Bait CoIP	20609350
Intra	Hif1a	Q61221	Arnt	Mus musculus	P53762	Pull Down	20609350

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0657	Pinoresinol Diglucoside		99.84%	Unkown
HY-RS06168	HIF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112068	DM-NOFD	Inhibitor	99.81%	Unkown
HY-100947A	cis VH-298		99.96%	Unkown
HY-RS16959	Hif1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123255	BSc2118		/	Unkown
HY-161838	ICT10336	Inhibitor	/	Unkown
HY-N13009	MO-2097		/	Unkown
HY-RS23402	Hif1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hif1a	NCBI	NCBI:3091