Peg10 - paternally expressed 10 Gene

Also Known as Edr; HB-1; Mar2; Rtl2; MEF3L; Mart2; MyEF-3; MmPEG10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170676

Summary

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, Apoptosis and Cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]

Peg10 Products (2)

mRNA Protein Name
NM_001040611.1 NP_001035701.1 retrotransposon-derived protein PEG10 isoform 2
NM_130877.2 NP_570947.2 retrotransposon-derived protein PEG10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
30951545 MGI
Biological Process GO Annotation Evidence References Source
involved in mRNA transport IDA
IDA: Inferred from direct assay
34413232 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
16341224 MGI
involved in protein homooligomerization IDA
IDA: Inferred from direct assay
34413232 MGI
involved in vesicle-mediated intercellular transport IDA
IDA: Inferred from direct assay
34413232 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30951545 MGI
is active in extracellular vesicle IDA
IDA: Inferred from direct assay
34413232 MGI
located in extracellular vesicle IDA
IDA: Inferred from direct assay
30951545 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retrotransposon-derived protein PEG10

  • MEF3-like protein 1

  • MyEF-3 like

  • embryonal carcinoma differentiation regulated protein

  • mammalian retrotransposon-derived protein 2

  • myelin expression factor 3

  • myelin expression factor 3-like protein 1

  • paternally expressed gene 10 protein

  • retrotranspo

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (79)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-140217 Azido-PEG10-amine ≥97.0% Unkown
HY-143855 Biotin-PEG10-NHS ester 98.02% Unkown
HY-133231 Bis-PEG10-acid ≥98.0% Unkown
HY-140759 Azido-PEG10-NHS ester 98.03% Unkown
HY-141120 Boc-NH-PEG10-NHS ester 98.0% Unkown
HY-130824 Bis-PEG10-NHS ester 95.0% Unkown
HY-138726 Mal-PEG10-NHS ester 98.0% Unkown
HY-W190857 N-Boc-PEG10-alcohol 98.0% Unkown
HY-139018A TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride 98.28% Unkown
HY-140226 m-PEG10-amine 99.97% Unkown
HY-W040270 Amino-PEG10-amine 97.0% Unkown
HY-126508 Mal-amido-PEG5-C2-​NHS ester ≥98.0% Unkown
HY-126509 Mal-amido-PEG10-C2-​NHS ester 98.0% Unkown
HY-140455 Azido-PEG10-acid 99.88% Unkown
HY-141218 m-PEG10-alcohol ≥97.0% Unkown
HY-RS10318 PEG10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W190862 Biotin-PEG10-azide 98.0% Unkown
HY-181228 DBCO-PEG10-Biotin / Unkown
HY-130424 m-PEG10-azide / Unkown
HY-135930 Boc-NH-PEG10-CH2CH2NH2 ≥98.0% Unkown
HY-140020 Propargyl-PEG10-acid 98.0% Unkown
HY-140304 DBCO-PEG10-DBCO 96.97% Unkown
HY-140500 m-PEG10-acid 98.0% Unkown
HY-140801 Azido-PEG10-alcohol 97.0% Unkown
HY-143827 Biotin-PEG10-amine 99.83% Unkown
HY-W019939 Hydroxy-PEG10-Boc / Unkown
HY-133304 HO-PEG10-CH2COOH 98.0% Unkown
HY-116027A Biotin-PEG10-acid / Unkown
HY-120761 Amino-PEG10-OH / Unkown
HY-132057 Bis-PEG10-t-butyl ester / Unkown
HY-132065 Decaethylene glycol dodecyl ether 99.91% Unkown
HY-132076 Azido-PEG10-azide / Unkown
HY-132081 Benzyl-PEG10-t-butyl ester / Unkown
HY-132098 Bis-propargyl-PEG10 / Unkown
HY-132118 Bromo-PEG10-t-butyl ester / Unkown
HY-133230 Propargyl-PEG10-amine / Unkown
HY-133270 m-PEG10-SH / Unkown
HY-133307 Hydroxy-PEG10-acid 99.59% Unkown
HY-133312 Hydroxy-PEG10-CH2-Boc / Unkown
HY-134718 Glycocholic acid-PEG10-iodoacetamide / Unkown
HY-134747 THP-PEG10-THP / Unkown
HY-138316 THP-PEG10-C2-Boc / Unkown
HY-138341 Benzyl-PEG10-THP / Unkown
HY-138344 MS-PEG10-THP / Unkown
HY-138347 THP-PEG10-Boc / Unkown
HY-138350 Azido-PEG10-CH2CO2-NHS / Unkown
HY-138390 NH2-PEG10-C2-dimethylamino / Unkown
HY-138413 THP-PEG10-OH / Unkown
HY-138416 Azido-PEG10-CH2COOH / Unkown
HY-138460 Propargyl-PEG10-alcohol / Unkown
HY-138713 Benzyl-PEG10-Ots / Unkown
HY-138721 Fmoc-PEG10-NHS ester / Unkown
HY-138722 Mal-PEG10-Boc / Unkown
HY-138723 Mal-PEG10-acid / Unkown
HY-138739 Azido-PEG10-propargyl / Unkown
HY-139018 TLR7/8 agonist 4 hydroxy-PEG10-acid / Unkown
HY-140029 Propargyl-PEG10-Boc / Unkown
HY-140360 m-PEG10-Tos / Unkown
HY-140386 Ms-PEG10-t-butyl ester / Unkown
HY-140781 Azido-PEG10-Boc / Unkown
HY-140861 Trityl-PEG10-azide / Unkown
HY-140973 Mal-amido-PEG10-acid / Unkown
HY-141104 m-PEG10-NHS ester / Unkown
HY-141130 LG-PEG10-click-DBCO-Oleic / Unkown
HY-141399 m-PEG10-T-Butyl ester / Unkown
HY-143828 t-Boc-N-amido-PEG10-Br / Unkown
HY-143836 Acid-PEG10-t-butyl ester / Unkown
HY-144076 t-Boc-amido-PEG10-acid / Unkown
HY-164654 DOTA-PEG10-azide Control / Unkown
HY-174919 Br-PEG10-OH / Unkown
HY-W096081 Benzyl-PEG10-alcohol / Unkown
HY-133335 Amino-PEG10-CH2-Boc / Unkown
HY-RS20078 Peg10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26581 Peg10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W800709 N-(acid-PEG10)-N-bis(PEG10-azide) / Unkown
HY-W800715 (Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane / Unkown
HY-W800716 Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine / Unkown
HY-W800717 Tetra-(amido-PEG10-azide) / Unkown
HY-W906996 PEG10-Tos / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Peg10 NCBI NCBI:23089