AFM - afamin Gene

Also Known as ALF; ALB2; ALBA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 173

About AFM

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,481,745-73,504,001 (from NCBI)

This gene has 2 transcripts (splice variants), 135 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 187.4).

Summary

This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]

AFM Products (1)

mRNA	Protein	Name
NM_001133.2	NP_001124.1	afamin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26902720	GOA
enables vitamin E binding	IDA IDA: Inferred from direct assay	15952736	GOA
enables vitamin E binding	IPI IPI: Inferred from physical interaction	12463752	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein stabilization	IDA IDA: Inferred from direct assay	26902720	GOA
involved in protein transport within extracellular region	IMP IMP: Inferred from mutant phenotype	26902720	GOA
involved in vitamin transport	IDA IDA: Inferred from direct assay	12463752	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12463752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AFM Protein Structure

Serum_albumin

0
100
200
300
400
500
599 a.a.

Protein Preferred Names	Protein Names
afamin	alpha-Alb

AFM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	AFM	P43652	Wnt3a	Mus musculus	P27467	GMS	26902720

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AFM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70036	Afamin/AFM Protein, Human (HEK293, His)	P43652 (L22-N599)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70036B	Afamin/AFM Protein, Human (587a.a, HEK293, His)	P43652 (L13-N599)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Squamous Papillomatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990710	Acimtamig		99.9%	Phase 2
HY-P990314	AFM24	Inhibitor	96.26%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125099A	AFM-30a hydrochloride	Inhibitor	99.66%	Unkown
HY-N0638	Dendrobine		99.92%	Unkown
HY-136557A	AFM32a hydrochloride	Inhibitor	99.37%	Unkown
HY-125099	AFM-30a	Inhibitor	≥96.0%	Unkown
HY-D0029	5(6)-Aminofluorescein		98.55%	Unkown
HY-136557	AFM32a	Inhibitor	/	Unkown
HY-RS00433	AFM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18890	Afm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25381	Afm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991552	AFM15	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AFM	VGNC	VGNC:69740
Bos taurus	AFM	VGNC	VGNC:25715
Canis familiaris	AFM	VGNC	VGNC:37691
Mus musculus	AFM	MGD	MGI:2429409
Rattus norvegicus	AFM	RGD	RGD:628614
Others	AFM	NCBI