Acimtamig
Based on 1 Customer Validation
Acimtamig (AFM13) is a CD30/CD16A bispecific innate cell engager. Acimtamig binds to the CD16A expressed on natural killer (NK) cells and binds to CD30 on CD30-expressing tumor cells, thereby selectively cross-linking tumor and NK cells. Acimtamig can be used for the study of eripheral T-cell lymphoma (PTCL).
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 2738880-26-5
- Molecular Weight:103.936 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
VH-V-kappa-VH'-V-lambda_tandAb
Human
TNFRSF8 & FCGR3A
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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VH-V-kappa-VH'-V-lambda_tandAb
ELISA, FACS, Functional assay
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Immobilized CD30/TNFRSF8 Protein, Human (HEK293, His, HY-P70023) can bind Acimtamig. The EC50 for this effect is 668.7 ng/mL. -
Immobilized Fc gamma RIIIA/CD16a Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78099) can bind Acimtamig. The EC50 for this effect is 714.0 ng/mL.
Chemical Information
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CAS No. 2738880-26-5
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Appearance Liquid
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Molecular Weight 103.936 kDa
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Color Colorless to light yellow
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SMILES
[Acimtamig]
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Synonyms
AFM13
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)