Nek2 - NIMA (never in mitosis gene a)-related expressed kinase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18005

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including blastocyst development; mitotic nuclear division; and negative regulation of DNA binding activity. Located in condensed nuclear chromosome; midbody; and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nek2 Products (2)

mRNA Protein Name
NM_010892.3 NP_035022.2 serine/threonine-protein kinase Nek2
NM_010892.3 NP_035022.2 serine/threonine-protein kinase Nek2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14668482 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14668482 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst development IMP
IMP: Inferred from mutant phenotype
19117032 MGI
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
19117032 MGI
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
15479717 MGI
acts upstream of or within mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
19117032 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: Inferred from direct assay
14668482 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
14697346 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
15479717 MGI
located in midbody IDA
IDA: Inferred from direct assay
15479717 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
15479717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek2

  • NIMA - related expressed kinase 2

  • NIMA-related expressed kinase 2

  • NIMA-related kinase 2

  • Nek2 kinase

  • never in mitosis A-related kinase 2

  • nimA-related protein kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-120356A T-1101 tosylate Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101029 MBM-55 Inhibitor 99.94% Unkown
HY-16660 INH1 Inhibitor 99.89% Unkown
HY-117154 INH154 99.89% Unkown
HY-156437 NBI-961 Inhibitor 99.73% Unkown
HY-116423 JH295 98.66% Unkown
HY-100541 INH6 Inhibitor 99.53% Unkown
HY-B0790 TAI-1 Inhibitor 98.60% Unkown
HY-101030A MBM-17S Inhibitor / Unkown
HY-137046 Nek2-IN-4 / Unkown
HY-116423A JH295 hydrate 99.0% Unkown
HY-153749 Nek2/Hec1-IN-2 98.0% Unkown
HY-101029A MBM-55S Inhibitor / Unkown
HY-101030 MBM-17 Inhibitor / Unkown
HY-108919 CG-1521 Inhibitor 95.71% Unkown
HY-111090 GSK461364 analogue 1 Inhibitor / Unkown
HY-150046 Nek2-IN-6 / Unkown
HY-120356 T-1101 Inhibitor / Unkown
HY-120330 Nek2-IN-5 99.17% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nek2 NCBI NCBI:4751